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少量结核分枝杆菌对人单核细胞进行体外感染对单核细胞凋亡的影响。

Effect of in vitro infection of human monocytes with low numbers of Mycobacterium tuberculosis bacteria on monocyte apoptosis.

作者信息

Dürrbaum-Landmann I, Gercken J, Flad H D, Ernst M

机构信息

Department of Immunology and Cell Biology, Forschungszentrum Borstel, Germany.

出版信息

Infect Immun. 1996 Dec;64(12):5384-9. doi: 10.1128/iai.64.12.5384-5389.1996.

Abstract

The effect of Mycobacterium tuberculosis H37Rv on spontaneous apoptosis of human monocytes from healthy donors in vitro was investigated. Infection with low numbers of viable M. tuberculosis bacteria prevented spontaneously occurring apoptosis in monocytes. Our data suggest that apoptosis of monocytes appears to be negatively associated with the presence of tumor necrosis factor alpha.

摘要

研究了结核分枝杆菌H37Rv对健康供体人单核细胞体外自发凋亡的影响。低数量活结核分枝杆菌感染可阻止单核细胞自发发生凋亡。我们的数据表明,单核细胞凋亡似乎与肿瘤坏死因子α的存在呈负相关。

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