结核分枝杆菌30千道尔顿抗原刺激单核细胞中肿瘤坏死因子α产生的调控
Regulation of production of tumor necrosis factor alpha in monocytes stimulated by the 30-kilodalton antigen of Mycobacterium tuberculosis.
作者信息
Averill L, Toossi Z, Aung H, Boom W H, Ellner J J
机构信息
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4984, USA.
出版信息
Infect Immun. 1995 Aug;63(8):3206-8. doi: 10.1128/iai.63.8.3206-3208.1995.
Abstract
The 30-kDa secreted antigen of Mycobacterium tuberculosis was a strong inducer of tumor necrosis factor alpha in human monocytes. Our findings suggest that tumor necrosis factor alpha production may be up-regulated at both the posttranscriptional and transcriptional levels. Regulation at the posttranscriptional level probably reflects enhanced translational efficiency.
摘要
结核分枝杆菌30 kDa分泌抗原是人类单核细胞中肿瘤坏死因子α的强诱导剂。我们的研究结果表明，肿瘤坏死因子α的产生可能在转录后和转录水平均上调。转录后水平的调控可能反映了翻译效率的提高。
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