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1
Either B7-1 or B7-2 is required for Listeria monocytogenes-specific production of gamma interferon and interleukin-2.单核细胞增生李斯特菌特异性产生γ干扰素和白细胞介素-2需要B7-1或B7-2。
Infect Immun. 1996 Dec;64(12):5439-41. doi: 10.1128/iai.64.12.5439-5441.1996.
2
Differential requirements for co-stimulatory signals from B7 family members by resting versus recently activated memory T cells towards soluble recall antigens.静息与近期活化的记忆T细胞对可溶性回忆抗原产生反应时，来自B7家族成员的共刺激信号的差异需求。
Int Immunol. 1996 Jan;8(1):37-44. doi: 10.1093/intimm/8.1.37.
3
Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection.内源性B7-H1的阻断会抑制原发性单核细胞增多性李斯特菌感染后的抗菌保护作用。
Immunology. 2008 Jan;123(1):90-9. doi: 10.1111/j.1365-2567.2007.02708.x. Epub 2007 Oct 25.
4
Blockade of B7-2, not B7-1, inhibits purified protein derivative-primed T-lymphocyte responses but fails to influence the proportion of Th1 versus Th2 subsets.阻断B7-2而非B7-1可抑制纯化蛋白衍生物致敏的T淋巴细胞反应，但不影响Th1与Th2亚群的比例。
Scand J Immunol. 1998 Apr;47(4):355-62. doi: 10.1046/j.1365-3083.1998.00315.x.
5
Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice.共刺激阻断可预防白细胞介素-10缺陷小鼠中感染诱导的免疫病理。
Infect Immun. 2000 May;68(5):2837-44. doi: 10.1128/IAI.68.5.2837-2844.2000.
6
Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes.人外周血单核细胞上CD80（B7-1）和CD86（B7-2）的差异表达及功能
Immunology. 1996 Dec;89(4):592-8. doi: 10.1046/j.1365-2567.1996.d01-785.x.
7
Augmentation of B7 expression by herpes simplex virus antigen.单纯疱疹病毒抗原增强B7表达。
Hum Immunol. 2003 Aug;64(8):780-6. doi: 10.1016/s0198-8859(03)00103-4.
8
Mitogenic stimulation of T cells reveals differing contributions for B7-1 (CD80) and B7-2 (CD86) costimulation.T细胞的有丝分裂原刺激揭示了共刺激分子B7-1（CD80）和B7-2（CD86）的不同作用。
Immunology. 1997 Apr;90(4):534-42. doi: 10.1046/j.1365-2567.04.00215.x.
9
B7 costimulatory ligand regulates development of the T-cell response to Cryptococcus neoformans.B7共刺激配体调节T细胞对新型隐球菌反应的发育。
Immunology. 1999 Sep;98(1):27-35. doi: 10.1046/j.1365-2567.1999.00853.x.
10
Differential expression of B7 co-stimulatory molecules by astrocytes correlates with T cell activation and cytokine production.星形胶质细胞B7共刺激分子的差异表达与T细胞活化及细胞因子产生相关。
Int Immunol. 1999 Jul;11(7):1169-79. doi: 10.1093/intimm/11.7.1169.

引用本文的文献

1
Interleukin-12 neutralization alters lung inflammation and leukocyte expression of CD80, CD86, and major histocompatibility complex class II in mice infected with Histoplasma capsulatum.白细胞介素-12中和作用可改变感染荚膜组织胞浆菌的小鼠的肺部炎症以及白细胞CD80、CD86和主要组织相容性复合体II类分子的表达。
Infect Immun. 2000 Apr;68(4):2069-76. doi: 10.1128/IAI.68.4.2069-2076.2000.

本文引用的文献

1
Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms.肿瘤坏死因子α和白细胞介素-12通过不同机制促成对细胞内细菌流产布鲁氏菌的抗性。
Infect Immun. 1996 Jul;64(7):2782-6. doi: 10.1128/iai.64.7.2782-2786.1996.
2
Immunity to intracellular bacteria.对细胞内细菌的免疫
Annu Rev Immunol. 1993;11:129-63. doi: 10.1146/annurev.iy.11.040193.001021.
3
Immune response in mice that lack the interferon-gamma receptor.缺乏干扰素-γ受体的小鼠的免疫反应。
Science. 1993 Mar 19;259(5102):1742-5. doi: 10.1126/science.8456301.
4
Cytokine production in the murine response to brucella infection or immunization with antigenic extracts.小鼠对布鲁氏菌感染或用抗原提取物免疫反应中的细胞因子产生。
Immunology. 1993 Nov;80(3):458-64.
5
Regulation of hepatic endothelial cell and macrophage proliferation and nitric oxide production by GM-CSF, M-CSF, and IL-1 beta following acute endotoxemia.急性内毒素血症后GM-CSF、M-CSF和IL-1β对肝内皮细胞和巨噬细胞增殖及一氧化氮产生的调节作用
J Leukoc Biol. 1994 Apr;55(4):507-13.
6
Interleukin-12 and its role in the generation of TH1 cells.白细胞介素-12及其在TH1细胞生成中的作用。
Immunol Today. 1993 Jul;14(7):335-8. doi: 10.1016/0167-5699(93)90230-I.
7
Surface proteins involved in T cell costimulation.参与T细胞共刺激的表面蛋白。
J Leukoc Biol. 1994 Jun;55(6):805-15. doi: 10.1002/jlb.55.6.805.
8
CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity.CD8 + T细胞通过穿孔素依赖性细胞毒性对细胞内细菌介导的保护作用。
Eur J Immunol. 1994 Dec;24(12):3068-72. doi: 10.1002/eji.1830241223.
9
Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.鉴定一种用于T细胞活化的替代性CTLA-4配体共刺激分子。
Science. 1993 Nov 5;262(5135):905-7. doi: 10.1126/science.7694361.
10
Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.巨噬细胞激活的非T细胞依赖性途径中一氧化氮的释放。其在抗单核细胞增生李斯特菌中的作用。
J Immunol. 1993 Feb 1;150(3):888-95.

单核细胞增生李斯特菌特异性产生γ干扰素和白细胞介素-2需要B7-1或B7-2。

Either B7-1 or B7-2 is required for Listeria monocytogenes-specific production of gamma interferon and interleukin-2.

作者信息

Zhan Y, Cheers C

机构信息

Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.

出版信息

Infect Immun. 1996 Dec;64(12):5439-41. doi: 10.1128/iai.64.12.5439-5441.1996.

DOI:10.1128/iai.64.12.5439-5441.1996
PMID:8945605
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174547/
Abstract

Listeria infection results in the induction of gamma interferon (IFN-gamma)-producing T lymphocytes. Blocking of the costimulatory molecule B7 in vivo led to a marked decrease in antigen-specific production of IFN-gamma and interleukin-2 by lymphocytes. Blocking of both B7-1 (CD80) and B7-2 (CD86) was required in order to inhibit cytokine production, indicating that either molecule could act alone. Although IFN-gamma production by cultured spleen cells was significantly suppressed by B7 blocking, mice cleared primary and secondary Listeria infection as effectively as control mice.

摘要

李斯特菌感染会诱导产生γ干扰素（IFN-γ）的T淋巴细胞。体内共刺激分子B7的阻断导致淋巴细胞抗原特异性产生的IFN-γ和白细胞介素-2显著减少。为了抑制细胞因子的产生，需要同时阻断B7-1（CD80）和B7-2（CD86），这表明任一分子都可单独发挥作用。尽管B7阻断可显著抑制培养的脾细胞产生IFN-γ，但小鼠清除原发性和继发性李斯特菌感染的效果与对照小鼠一样有效。