白蛉传播媒介唾液对BALB/c小鼠皮肤病变发展及巴西利什曼原虫免疫反应的影响。
Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice.
作者信息
Lima H C, Titus R G
机构信息
Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523-1671, USA.
出版信息
Infect Immun. 1996 Dec;64(12):5442-5. doi: 10.1128/iai.64.12.5442-5445.1996.
Abstract
The saliva of the sand fly vector of leishmaniasis significantly enhanced infection with doses of >10(4) Leishmania braziliensis parasites in BALB/c mice. With a dose of 10(7) L. braziliensis parasites, 60 to 70% of the mice developed lifetime infections. Mice infected with L. braziliensis plus saliva produced two- to threefold more interleukin-4 than did mice infected with L. braziliensis alone. Treatment with a neutralizing anti-interleukin-4 antibody abrogated the effects of the saliva.
摘要
利什曼病沙蝇传播媒介的唾液显著增强了 BALB/c 小鼠感染剂量大于 10⁴巴西利什曼原虫寄生虫的能力。给予 10⁷巴西利什曼原虫寄生虫剂量时，60%至 70%的小鼠发生终身感染。感染巴西利什曼原虫加唾液的小鼠产生的白细胞介素-4 比仅感染巴西利什曼原虫的小鼠多两到三倍。用中和性抗白细胞介素-4 抗体治疗可消除唾液的作用。
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