升麻属植物的成分研究。十九。单穗升麻中的八个新糖苷

Studies on the constituents of Cimicifuga species. XIX. Eight new glycosides from Cimicifuga simplex Wormsk.

作者信息

Kusano A, Shibano M, Kusano G, Miyase T

机构信息

Osaka University of Pharmaceutical Sciences, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1996 Nov;44(11):2078-85. doi: 10.1248/cpb.44.2078.

DOI:10.1248/cpb.44.2078

PMID:8945773

Abstract

Eight new glycosides were isolated from Cimicifuga simplex (Ranunculaceae), and their structures were determined to be 23-O-acetyl-7-8-didehydroshengmanol-3-O-alpha-L-arabinopyranosi de (1), 24-epi-24-O-acetyl-7,-8- didehydrohydroshengmanol-3-O-beta-D-galactopyranoside (2), 7,8-didehydrocimigenol-3-O-beta-D-galacytopyranoside (3), 24-epi-24-O-acetylhydroshengmanol-3-O-beta-D-galactopyranoside (4), cimigenol-3-O-beta-D-galactopyranoside (5), 25-O-methylcimigenol-3-O-beta-D-galactopyranoside (6), 25-O-acetylcimigenol-3-O-beta-D-galactopyranoside (7) and 25-O-acetylcimigenol-3-O-beta-D-glucopyranoside (8). Genuine aglycones were obtained by the hydrolysis of 1--7 with lactase F[Amano] and of 8 with cellulase T[amano]4. Acerinol was prepared from 7,8-didehydrocimigenol and showed antilipemic effects.

摘要

从单穗升麻（毛茛科）中分离出8种新糖苷，其结构确定为23 - O - 乙酰基 - 7,8 - 二脱氢升麻醇 - 3 - O - α - L - 阿拉伯吡喃糖苷（1）、24 - 表 - 24 - O - 乙酰基 - 7,8 - 二脱氢氢化升麻醇 - 3 - O - β - D - 吡喃半乳糖苷（2）、7,8 - 二脱氢升麻亭醇 - 3 - O - β - D - 吡喃半乳糖苷（3）、24 - 表 - 24 - O - 乙酰基氢化升麻醇 - 3 - O - β - D - 吡喃半乳糖苷（4）、升麻亭醇 - 3 - O - β - D - 吡喃半乳糖苷（5）、25 - O - 甲基升麻亭醇 - 3 - O - β - D - 吡喃半乳糖苷（6）、25 - O - 乙酰基升麻亭醇 - 3 - O - β - D - 吡喃半乳糖苷（7）和25 - O - 乙酰基升麻亭醇 - 3 - O - β - D - 吡喃葡萄糖苷（8）。通过用乳糖酶F（天野）水解1 - 7以及用纤维素酶T（天野）4水解8获得了真正的苷元。从7,8 - 二脱氢升麻亭醇制备了落新妇醇，其具有降血脂作用。