Matysiak-Budnik T, Knapik Z, Mégraud F, Lubczynska-Kowalska W, Gosciniak G, Bouchard S, Przondo-Mordarska A, Poniewierka E, Helemejko M, Klempous J
Department and Clinic of Gastroenterology, Medical University of Wroclaw, Poland.
Am J Gastroenterol. 1996 Dec;91(12):2513-5.
The Helicobacter pylori status of the population of Eastern European countries has not been explored despite the high incidence of peptic ulcer disease and gastric cancer observed in these countries. A seroprevalence study has been performed in Wroclaw, a city of Lower Silesia, Poland, to provide insight into this question. Sera were collected to obtain 50 subjects per 5 yr increment of age. A second generation ELISA kit with a high sensitivity and specificity was used. The results plotted by year of birth show a very high prevalence of H. pylori infection in all adults groups born before 1970 (80-100% positive). In the younger age groups, a dramatic decrease was observed. Because it is now known that most H. pylori infections are acquired in childhood (cohort effect), it can be predicted that the infection rate in the adult population will be much lower in the future compared with that presently observed, and it can be expected that evolution in H. pylori prevalence will have an impact on the rate of gastroduodenal diseases in Poland. Because of the high prevalence, it was not possible to identify risk factors for infection in this population.
尽管在东欧国家观察到消化性溃疡疾病和胃癌的高发病率，但这些国家人群的幽门螺杆菌感染状况尚未得到研究。在波兰下西里西亚省的弗罗茨瓦夫市进行了一项血清流行率研究，以深入了解这个问题。按每5岁年龄增量收集血清样本，共获得50名受试者。使用了一种高灵敏度和特异性的第二代酶联免疫吸附测定试剂盒。按出生年份绘制的结果显示，1970年以前出生的所有成年组中幽门螺杆菌感染率非常高（阳性率为80%-100%）。在较年轻的年龄组中，观察到感染率急剧下降。由于现在已知大多数幽门螺杆菌感染是在儿童期获得的（队列效应），可以预测，与目前观察到的情况相比，未来成年人群中的感染率将低得多，并且可以预期幽门螺杆菌流行率的变化将对波兰胃十二指肠疾病的发病率产生影响。由于感染率很高，因此无法在该人群中确定感染的风险因素。
