Pugh C R, Arger P H, Sehgal C M
Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104-6010, USA.
J Ultrasound Med. 1996 Dec;15(12):843-52. doi: 10.7863/jum.1996.15.12.843.
The ability of EchoGen contrast agent (Sonus Pharmaceuticals, Bothell, WA) to enhance aortic, renal, and scrotal spectral Doppler, color flow, and power Doppler sonography at doses from 0.01 ml/kg to 0.65 ml/kg was evaluated in dogs. Videotaped images were digitized and analyzed for Doppler signal strength at known postinjection times. Contrast agent increased aortic spectral Doppler peak height, spectral width, and brightness. Contrast agent increased renal and testicular color flow and power Doppler sonographic signal and enhanced the visualization of vascular anatomy. Intensity and duration of these effects increased with increasing dose of contrast agent. Enhancement effect varied in different organs. At higher doses, blooming and Doppler shift artifacts were observed and are believed to be due to machine limitation.
在犬类中评估了EchoGen造影剂（华盛顿州博塞尔市索努斯制药公司生产）在0.01 ml/kg至0.65 ml/kg剂量下增强主动脉、肾脏和阴囊频谱多普勒、彩色血流及能量多普勒超声检查的能力。对录像图像进行数字化处理，并在已知的注射后时间分析多普勒信号强度。造影剂增加了主动脉频谱多普勒的峰值高度、频谱宽度和亮度。造影剂增加了肾脏和睾丸的彩色血流及能量多普勒超声信号，并增强了血管解剖结构的可视化。这些效应的强度和持续时间随造影剂剂量的增加而增加。增强效果在不同器官中有所不同。在较高剂量下，观察到了造影剂外溢和多普勒频移伪像，据信这是由于机器限制所致。
