Lightowlers M W, Rolfe R, Gauci C G
Molecular Parasitology Laboratory, University of Melbourne, Werribee, Victoria, Australia.
Exp Parasitol. 1996 Dec;84(3):330-8. doi: 10.1006/expr.1996.0121.
Taenia saginata is a medically and economically important cestode parasite. Infection with the cysticercus larval stage in cattle causes economic loss in the beef meat industry. A practical vaccine to prevent infection with the parasite in cattle would be valuable and would assist in control of transmission of the parasite to humans, the obligate definitive host. Here we use recombinant DNA techniques to clone oncosphere antigens of T. saginata and use the recombinant antigens in vaccine trials in cattle. Vaccination with a combination of two antigens, designated TSA-9 and TSA-18, induced up to 99.8% protection against experimental challenge infection with T. saginata eggs. Operational characteristics of the vaccine will need to be defined, such as duration of immunity and protection of newborn calves. The vaccine has the potential to be used on a commercial scale for the control of bovine cysticercosis.
牛带绦虫是一种在医学和经济方面都很重要的绦虫寄生虫。牛感染囊尾蚴幼虫阶段会给牛肉行业造成经济损失。一种实用的预防牛感染该寄生虫的疫苗将很有价值，并且有助于控制该寄生虫向其终末宿主——人类的传播。在此，我们运用重组DNA技术克隆牛带绦虫六钩蚴抗原，并将重组抗原用于牛的疫苗试验。用两种名为TSA - 9和TSA - 18的抗原组合进行疫苗接种，可诱导产生高达99.8%的针对牛带绦虫虫卵实验性攻击感染的保护作用。需要确定该疫苗的操作特性，如免疫持续时间和对新生犊牛的保护作用。这种疫苗有潜力用于商业规模的牛囊尾蚴病防控。
