Lisse I M, Poulsen A G, Aaby P, Knudsen K, Dias F
Department of Pathology, Hvidovre Hospital, Denmark.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):355-62. doi: 10.1097/00042560-199612010-00009.
In an urban community in Guinea-Bissau, we followed a cohort of human immunodeficiency virus type 2 (HIV-2) seropositive individuals (N = 47) and seronegative controls (N = 82). T-lymphocyte subset determinations were done in 1988, 1990, and 1992. Serial determinations of CD4 percentages, CD8 percentages, and CD4/CD8 ratios for the same individual were stable for 31 seropositive and 51 seronegative individuals with repeated measurements. We found no significant differences in the changes during a 2- or 4-year period in CD4 percentages, CD8 percentages, absolute CD8 T-lymphocyte counts, CD4/CD8 ratio, white blood cell counts, lymphocyte percentages, and absolute lymphocyte counts for HIV-2-seropositive compared with HIV-2-seronegative individuals. Only absolute CD4 T-lymphocyte counts changed more for the HIV-2-seropositive than for HIV-2-seronegative individuals (p = 0.037). HIV-2-infected individuals who lived with an HIV-2-infected spouse had a lower CD4/CD8 ratio and had higher mortality than HIV-2 infected individuals who lived with an uninfected spouse. However, there were no significant differences in immunological and hematological values for the 8 HIV-2 seropositive individuals who died and the 39 who survived in the 8-year follow-up period. In conclusion, progression of immunosuppression in HIV-2 infection seems to be slower than in HIV-1 infection and may not be inevitable in all individuals.
在几内亚比绍的一个城市社区，我们对一组2型人类免疫缺陷病毒（HIV-2）血清阳性个体（N = 47）和血清阴性对照者（N = 82）进行了随访。在1988年、1990年和1992年进行了T淋巴细胞亚群测定。对31名血清阳性个体和51名血清阴性个体进行了重复测量，同一人的CD4百分比、CD8百分比和CD4/CD8比值的系列测定结果是稳定的。我们发现，与HIV-2血清阴性个体相比，HIV-2血清阳性个体在2年或4年期间CD4百分比、CD8百分比、CD8 T淋巴细胞绝对计数、CD4/CD8比值、白细胞计数、淋巴细胞百分比和淋巴细胞绝对计数的变化没有显著差异。只有HIV-2血清阳性个体的CD4 T淋巴细胞绝对计数变化比HIV-2血清阴性个体更大（p = 0.037）。与未感染配偶生活在一起的HIV-2感染个体相比，与感染HIV-2配偶生活在一起的HIV-2感染个体的CD4/CD8比值更低，死亡率更高。然而，在8年的随访期内，8名死亡的HIV-2血清阳性个体和39名存活个体的免疫和血液学值没有显著差异。总之，HIV-2感染中免疫抑制的进展似乎比HIV-1感染慢，而且可能并非在所有个体中都不可避免。
