Finn C A, Pope M D, Milligan S R
Department of Veterinary Preclinical Sciences, University of Liverpool, United Kingdom.
Biol Reprod. 1996 Dec;55(6):1415-8. doi: 10.1095/biolreprod55.6.1415.
The nature of the physiological stimulus inducing decidualization in the endometrium is unknown. In this study we attempted to verify a recent report that relaxin can induce decidualization in intact mice primed with a high dose of estradiol valerate (5 micrograms) and a low dose (10 micrograms) of medroxyprogesterone acetate. In our study, neither s.c. nor intrauterine relaxin, nor intraluminal arachis oil, (an established deciduogenic stimulus) were able to induce decidualization. In addition, while oil was able to induce decidualization (increased uterine weight, and positive Pontamine Sky Blue and stromal alkaline phosphatase reactions) in ovariectomized mice treated with a regimen of estradiol and medroxyprogesterone acetate designed to produce optimum uterine sensitivity, no decidualization occurred in response to either s.c. or intraluminal relaxin. This study fails to provide any support for a role for relaxin as a deciduogenic stimulus.
诱导子宫内膜蜕膜化的生理刺激的本质尚不清楚。在本研究中，我们试图验证最近的一份报告，即松弛素可在经高剂量戊酸雌二醇（5微克）和低剂量醋酸甲羟孕酮（10微克）预处理的完整小鼠中诱导蜕膜化。在我们的研究中，皮下注射或子宫内注射松弛素，以及管腔内注射花生油（一种已确定的蜕膜化刺激物）均不能诱导蜕膜化。此外，虽然花生油能够在接受旨在产生最佳子宫敏感性的雌二醇和醋酸甲羟孕酮治疗方案的去卵巢小鼠中诱导蜕膜化（子宫重量增加，以及庞塔明天蓝和基质碱性磷酸酶反应呈阳性），但皮下注射或管腔内注射松弛素均未引发蜕膜化。本研究未能为松弛素作为蜕膜化刺激物的作用提供任何支持。
