Brandon J M
Department of Zoology, University of Oxford, UK.
J Reprod Fertil. 1990 Jan;88(1):151-8. doi: 10.1530/jrf.0.0880151.
Unilaterally ovariectomized mice were allowed to complete one pregnancy before the second ovary was removed and sensitivity to decidualization was induced by hormone administration. The virgin uterine horn and the post-partum horn were stimulated to decidualize by the intraluminal injection of arachis oil. A greater decidual response was found in post-partum horns than in virgin horns. The foci of decidual induction in post-partum horns were regularly spaced reflecting the regular spacing of used and unused areas of the uterus. A focus of decidual induction occurred in 68% of the recently used uterine areas observed, i.e. areas associated with post-partum nodules. When compared with foci of decidualization in adjacent unused areas of the uterus, none of the decidualized used zones showed more decidual tissue, about half showed less decidual tissue and half showed the same amount of decidual tissue. The remaining 32% of used zones were not associated with foci of decidual induction. The results indicate that decidualization can be induced in recently used zones of the uterus using a non-traumatic method of induction, but that used zones are associated with less decidual tissue than unused zones of the post-partum uterus.
对单侧卵巢切除的小鼠，先让其完成一次妊娠，然后再切除另一侧卵巢，并通过给予激素诱导蜕膜化敏感性。通过向子宫腔内注射花生油来刺激未生育小鼠的子宫角和产后子宫角发生蜕膜化。结果发现，产后子宫角的蜕膜反应比未生育小鼠的子宫角更强。产后子宫角中蜕膜诱导灶分布规律，反映了子宫已用区域和未用区域的规律分布。在所观察到的近期使用过的子宫区域中，即与产后小结节相关的区域，68%出现了蜕膜诱导灶。与子宫相邻未用区域的蜕膜化灶相比，已发生蜕膜化的已用区域中，没有一个区域的蜕膜组织更多，约一半区域的蜕膜组织更少，另一半区域的蜕膜组织量相同。其余32%的已用区域未出现蜕膜诱导灶。结果表明，使用非创伤性诱导方法可在子宫近期使用过的区域诱导蜕膜化，但已用区域的蜕膜组织比产后子宫的未用区域少。
