Milligan S R
J Reprod Fertil. 1987 Jan;79(1):251-9. doi: 10.1530/jrf.0.0790251.
The tissue accumulation of 125I-labelled human serum albumin 30 min after intravenous injection was used as an index of uterine vascular permeability. In ovariectomized mice, all sham and experimental instillation procedures produced a 6-10-fold increase in vascular permeability. Some effects were also manifest in the contralateral, control horn. In ovariectomized rats, instillation of saline and arachis oil increased vascular permeability 3-7-fold. After 3 or more days of progesterone treatment following oestradiol priming, fluorocarbon and arachis oil instillation produced marked vascular responses, but these were not restricted to the transient period in which the uterus would respond with decidualization. An IUD prevented the response to arachis oil instillation. These results indicate that the uterus is very sensitive to any manipulation and are consistent with decidualization representing a specialization of a normal uterine inflammatory response.
静脉注射125I标记的人血清白蛋白30分钟后的组织蓄积被用作子宫血管通透性的指标。在去卵巢小鼠中，所有假手术和实验性灌注程序均使血管通透性增加了6至10倍。对侧对照角也有一些影响。在去卵巢大鼠中，灌注生理盐水和花生油可使血管通透性增加3至7倍。在雌二醇预处理后用孕酮治疗3天或更长时间后，氟碳化合物和花生油灌注产生明显的血管反应，但这些反应并不局限于子宫会发生蜕膜化反应的短暂时期。宫内节育器可阻止对花生油灌注的反应。这些结果表明，子宫对任何操作都非常敏感，并且与蜕膜化代表正常子宫炎症反应的特化一致。
