Laskawi R, Wolff J R
Universitäts-HNO-Klinik, Göttingen, Germany.
Eur Arch Otorhinolaryngol. 1996;253(8):475-80. doi: 10.1007/BF00179953.
We report about changes on astrocytes in the facial nucleus of the rat following various types of peripheral nerve lesions. Astrocyte-specific glial fibrillary acidic protein (GFAP) was labeled by immunohistochemistry and served as a marker for these changes. Increased GFAP immunoreactivity was found in the facial nucleus on the lesioned side within 2-3 days after axotomy. This change lasted longer (up to 1 year) when axon regeneration was prevented or delayed by placing a metal clip on the proximal nerve stump. Lesion of the trigeminal nerve prior to axotomy reduced the degree of GFAP immunoreactivity. No side differences were observed after botulinum toxin application.
我们报告了大鼠面神经核中星形胶质细胞在各种类型的周围神经损伤后的变化。通过免疫组织化学标记星形胶质细胞特异性胶质纤维酸性蛋白（GFAP），并将其作为这些变化的标志物。在轴突切断后2 - 3天内，在损伤侧的面神经核中发现GFAP免疫反应性增加。当通过在近端神经残端放置金属夹阻止或延迟轴突再生时，这种变化持续时间更长（长达1年）。轴突切断术前三叉神经损伤降低了GFAP免疫反应性的程度。应用肉毒杆菌毒素后未观察到侧别差异。
