He Q, Edelman K, Arvilommi H, Mertsola J
National Public Health Institute, Department in Turku, Finland.
Eur J Clin Microbiol Infect Dis. 1996 Oct;15(10):793-8. doi: 10.1007/BF01701521.
An outbreak of parapertussis was studied prospectively in 38 first and second grade pupils of an elementary school. Eleven (29%) children were confirmed to be culture positive for Bordetella parapertussis. Serum samples were collected from 31 children for assay of antibodies to filamentous hemagglutinin (FHA), pertactin (PRN), and pertussis toxin of Bordetella pertussis. At the first sampling, ten children were found to have a cough and 21 were asymptomatic. Of the latter, 12 remained asymptomatic and eight developed cough within 11 to 53 days (mean +/- standard deviation, 31 +/- 12 days) after sampling. One child was identified as culture positive for Bordetella pertussis and, thus, not included in the analysis of Bordetella parapertussis infection. The mean levels of IgC antibodies to FHA and PRN were significantly higher in the 12 asymptomatic children than in the eight children who later developed cough or in 20 healthy control children of the same age (for FHA, p = 0.009 and < 0.001, respectively; for PRN, p = 0.002 and 0.002, respectively). These preliminary data suggest that Bordetella parapertussis infection is more prevalent than documented, and that children with high levels of IgG antibodies to FHA and PRN can remain asymptomatic.
对一所小学的38名一、二年级学生进行了百日咳杆菌感染暴发的前瞻性研究。11名（29%）儿童被确诊百日咳博德特氏菌培养阳性。采集了31名儿童的血清样本，用于检测针对百日咳博德特氏菌丝状血凝素（FHA）、百日咳黏附素（PRN）和百日咳毒素的抗体。首次采样时，10名儿童有咳嗽症状，21名无症状。在后者中，12名儿童一直无症状，8名在采样后11至53天（平均±标准差，31±12天）内出现咳嗽。1名儿童被确诊百日咳博德特氏菌培养阳性，因此未纳入百日咳博德特氏菌感染分析。12名无症状儿童中针对FHA和PRN的IgG抗体平均水平显著高于后来出现咳嗽的8名儿童或20名同龄健康对照儿童（针对FHA，p值分别为0.009和<0.001；针对PRN，p值分别为0.002和0.002）。这些初步数据表明，百日咳博德特氏菌感染比记录的更为普遍，且针对FHA和PRN的IgG抗体水平高的儿童可保持无症状。
