Leng H M, Folb P I
Department of Pharmaceutical Chemistry, University of the Western Cape, Bellville, South Africa.
Inflamm Res. 1996 Nov;45(11):541-5. doi: 10.1007/BF02342224.
Erythropoietin (Epo) production during acute inflammation induced by s. c. turpentine administration in experimental Long-Evans rats increased in response to reduced erythropoiesis. A close correlation was found between decreased haematocrit (Hct) and increased levels of tumour necrosis factor-alpha (TNF alpha) in this experimental system. The Epo response was not different between rats with acute inflammation and anaemia and control animals with a comparable degree of anaemia. It is concluded that Epo is not an acute phase reactant, and that the Epo response in acute experimental inflammation in rats is explained by the associated development of anaemia.
在实验性Long-Evans大鼠中，皮下注射松节油诱导急性炎症期间，促红细胞生成素（Epo）的产生因红细胞生成减少而增加。在该实验系统中，发现血细胞比容（Hct）降低与肿瘤坏死因子-α（TNFα）水平升高密切相关。急性炎症大鼠和贫血大鼠与具有相当程度贫血的对照动物之间的Epo反应没有差异。得出的结论是，Epo不是一种急性期反应物，并且大鼠急性实验性炎症中的Epo反应是由相关的贫血发展所解释的。
