尼古丁对大鼠胃泌素和肽YY的影响。

Influence of nicotine on gastrin and peptide YY in the rat.

作者信息

Gomez G, Lambertz I, Udupi V, Qi X, Thompson J C, Greeley G H

机构信息

Department of Surgery, University of Texas Medical Branch, Galveston 77555-0725, USA.

出版信息

Regul Pept. 1996 Nov 14;67(1):55-61. doi: 10.1016/s0167-0115(96)00107-3.

DOI:10.1016/s0167-0115(96)00107-3

PMID:8952006

Abstract

The objective of this study was to examine the effects of nicotine and high-fat diets on gastrin and peptide YY (PYY) homeostasis in the rat. Antral levels of gastrin mRNA and peptide and ileal and colonic levels of PYY mRNA and peptide were examined. Serum levels of gastrin in response to food were also measured. Control rats were ad-lib fed or pair-fed according to the daily food intake of nicotine-treated rats. The results of this study indicate that nicotine treatment and fat diets can influence gastrin and PYY gene expression in the gastrointestinal tract.

摘要

本研究的目的是检测尼古丁和高脂饮食对大鼠胃泌素和肽YY（PYY）体内稳态的影响。检测了胃窦部胃泌素mRNA和肽的水平以及回肠和结肠中PYY mRNA和肽的水平。还测定了食物刺激后血清胃泌素水平。根据尼古丁处理大鼠的每日食物摄入量，对对照大鼠进行自由采食或配对喂养。本研究结果表明，尼古丁处理和高脂饮食可影响胃肠道中胃泌素和PYY基因的表达。