Kirchhof N, Scheidemann W, Baumgärtner W
Institut für Veterinär-Pathologie, Giessen, Germany.
Vet Pathol. 1996 Nov;33(6):727-30. doi: 10.1177/030098589603300618.
Multiple neurofibromas, schwannomas, and hyperplastic enteric plexuses were observed in the distal jejunum and ileum of a 6-year-old pinto gelding. The animal was presented because of an acute episode of colic. Three meters of distal small intestine, partially incarcerated in the epiploic foramen, were surgically removed. Numerous tumor nodules up to 10 mm in diameter were found adjacent to a Meckel's diverticulum, predominantly located in the subserosa of a hypertrophic segment. Histologically, tumors were well demarcated and composed of interlacing fascicles formed by spindloid cells. Adjacent enteric plexuses were hyperplastic. Immunohistochemically, all tumors were positive for vimentin and S-100. Desmin immunoreactivity was only observed in larger tumors (> 500 microns). Glial fibrillary acid protein was demonstrated nearly exclusively in smaller ones. Immunostaining for neurofilament was restricted to entrapped ganglion cells. Based on conventional light microscopic examination and immunohistochemical evaluation, the lesion was diagnosed as multiple benign peripheral nerve sheath tumors in the small intestine.
在一匹6岁的花斑色雄性马的空肠远端和回肠中观察到多个神经纤维瘤、神经鞘瘤和增生性肠神经丛。该动物因急性腹痛发作就诊。手术切除了3米长的远端小肠，其部分嵌顿于网膜孔。在梅克尔憩室附近发现了许多直径达10毫米的肿瘤结节，主要位于肥厚段的浆膜下层。组织学上，肿瘤界限清楚，由梭形细胞形成的交错束状结构组成。相邻的肠神经丛增生。免疫组织化学显示，所有肿瘤波形蛋白和S-100均呈阳性。结蛋白免疫反应仅在较大的肿瘤（>500微米）中观察到。胶质纤维酸性蛋白几乎仅在较小的肿瘤中显示。神经丝免疫染色仅限于被困的神经节细胞。基于传统光学显微镜检查和免疫组织化学评估，该病变被诊断为小肠多发性良性周围神经鞘瘤。
