Tauchi H, Hasegawa K
Mech Ageing Dev. 1977 Sep-Oct;6(5):333-9. doi: 10.1016/0047-6374(77)90034-3.
The hepatic cells of the parabiotic unions 3 to 9 months after uniting between old and young rats were micrometrically examined. In the older parabiotic partners, it cannot be denied that the character of the findings tended in part towards that of the young controls. In the younger parabiotic partners, the estimated number of hepatic cells was apparently decreased, size of the hepatic cells and their nuclei was significantly increased, and number of binucleate hepatic cells was markedly increased. The findings of the hepatic cells in the younger partners were similar to those in the old controls. From the results, it is inferred that the proliferation of the hepatic cells of the younger parabiotic partners is inhibited by the inhibitory factors for cell division secreted from the hepatic cells of the older partners.
对老年和幼年大鼠联体3至9个月后的联体肝脏细胞进行了显微镜测量检查。在老年联体伙伴中，不可否认的是，部分检查结果的特征倾向于年轻对照组。在幼年联体伙伴中，估计的肝细胞数量明显减少，肝细胞及其细胞核的大小显著增加，双核肝细胞的数量显著增加。幼年伙伴中肝细胞的检查结果与老年对照组相似。从结果推断，幼年联体伙伴肝细胞的增殖受到老年伙伴肝细胞分泌的细胞分裂抑制因子的抑制。
