Benigni F, Sacco S, Pennica D, Ghezzi P
Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, Milan, Italy.
Am J Pathol. 1996 Dec;149(6):1847-50.
Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines that includes interleukin-6, interleukin-11, ciliary neurotrophic factor, leukemia inhibitory factor, and oncostatin M. As interleukin-6, leukemia inhibitory factor, and ciliary neurotrophic factor were previously reported to inhibit the production of tumor necrosis factor (TNF), we studied the effect of CT-1 on serum and heart TNF levels in mice treated with lipopolysaccharide (100 ng/mouse, iv). Co-treatment with CT-1 (5 micrograms/mouse intravenously) markedly inhibit TNF production both in serum and in the heart. The effect of CT-1 seems to be direct as it also inhibited TNF production when added to whole mouse blood cultured with lipopolysaccharide. Thus, CT-1 might play a protective role in some TNF-mediated diseases.
心肌营养素-1（CT-1）是gp130细胞因子家族的成员，该家族包括白细胞介素-6、白细胞介素-11、睫状神经营养因子、白血病抑制因子和制瘤素M。由于先前报道白细胞介素-6、白血病抑制因子和睫状神经营养因子可抑制肿瘤坏死因子（TNF）的产生，我们研究了CT-1对用脂多糖（100 ng/小鼠，静脉注射）处理的小鼠血清和心脏TNF水平的影响。与CT-1（5微克/小鼠静脉注射）共同处理可显著抑制血清和心脏中的TNF产生。CT-1的作用似乎是直接的，因为当将其添加到用脂多糖培养的全血中时，它也能抑制TNF的产生。因此，CT-1可能在某些TNF介导的疾病中发挥保护作用。
