Beani J C
Clinique dermatologique, CHU A-Michallon, Grenoble, France.
Bull Cancer. 1996 Sep;83(9):755-7.
Skin carcinoma is the most frequent of all cancers. The main risk factor is represented by solar exposition and, so, individuals with special risk are xeroderma pigmento sum (enzymatic defect of DNA repair), light phototype person, sun-seekers, outdoor-workers and patients treated with high doses of PUVA. X-rays, mineral oils, tar and arsenic are also known skin carcinogens. HPV can also participate to skin carcinogenis alone or associated with UV particularly in immunosupressed sujets. Subjects with predisposition for skin carcinoma can be pointed out and cautioned. Detection of preepitheliomatous lesions is easy; actinic keratosis are the main signs.
皮肤癌是所有癌症中最常见的。主要危险因素是日晒，因此，具有特殊风险的个体包括着色性干皮病（DNA修复酶缺陷）、浅肤色人群、爱晒太阳的人、户外工作者以及接受高剂量补骨脂素加长波紫外线（PUVA）治疗的患者。X射线、矿物油、焦油和砷也是已知的皮肤致癌物。人乳头瘤病毒（HPV）也可单独或与紫外线相关参与皮肤致癌过程，尤其是在免疫抑制患者中。具有皮肤癌易感性的个体可以被识别并得到警示。上皮瘤前病变很容易检测；光化性角化病是主要体征。
