Dueymes M, Levy Y, Ziporen L, Jamin C, Piette J C, Shoenfeld Y, Youinou P
Laboratoire d'Immunologie, CHU, Brest, France.
Ann Med Interne (Paris). 1996 Sep;147 Suppl 1:22-3.
Anti-endothelial cell activity is partly due to antiphospholipid antibodies (aPLA) because: a) the two types of antibodies are present in patients with connective tissue diseases and cardiolipin-binding monoclonal antibodies recognize endothelial cells (EC); b) anionic phospholipids are detectable on the outer face of the EC membrane lipid bilayer and an anti-beta 2-glycoprotein I (beta 2-GPI) monoclonal antibody binds to EC; c) the binding of aPLA to EC and the functional affinity of this binding are dependent on the presence of beta 2-GPI; d) anti-EC antibodies trigger the expression of anionic phospholipids on the outer leaflet of the EC membrane.
抗内皮细胞活性部分归因于抗磷脂抗体（aPLA），原因如下：a）结缔组织病患者体内存在这两种抗体，且心磷脂结合单克隆抗体可识别内皮细胞（EC）；b）在EC膜脂质双层的外表面可检测到阴离子磷脂，抗β2糖蛋白I（β2-GPI）单克隆抗体可与EC结合；c）aPLA与EC的结合以及这种结合的功能亲和力取决于β2-GPI的存在；d）抗EC抗体可触发EC膜外层小叶上阴离子磷脂的表达。
