Brizzi M, Thorén A, Hindfelt B
Department of Neurology, Malmö University Hospital, Sweden.
Scand J Infect Dis. 1996;28(5):455-8. doi: 10.3109/00365549609037939.
Current therapy of bacterial meningitis includes high doses of antibiotics and, sometimes, addition of corticosteroids in order to reduce a harmful inflammatory response. The persisting high mortality and rate of sequelae, particularly regarding pneumococcal meningitis, calls for new therapeutic approaches. We report a case of a 71-year-old female with a pneumococcal meningitis treated with extra-corporeal filtration of cerebrospinal fluid (CSF) after 3 days of coma on conventional treatment. The treatment was carried out without complications and the clinical outcome was favourable. We suggest that filtration of the CSF should be considered as a tool to eliminate noxious substances playing a harmful role in deteriorating course of bacterial meningitis.
目前细菌性脑膜炎的治疗方法包括大剂量使用抗生素，有时还会加用皮质类固醇以减轻有害的炎症反应。持续的高死亡率和后遗症发生率，尤其是肺炎球菌性脑膜炎，需要新的治疗方法。我们报告了一例71岁女性肺炎球菌性脑膜炎患者，在常规治疗昏迷3天后接受了脑脊液（CSF）体外过滤治疗。治疗过程无并发症，临床结果良好。我们建议脑脊液过滤应被视为一种消除在细菌性脑膜炎恶化过程中起有害作用的有害物质的手段。
