Berglund J, Eitrem R, Norrby S R
Department of Community Health Sciences, University of Lund, Sweden.
Scand J Infect Dis. 1996;28(5):473-8. doi: 10.3109/00365549609037943.
From May 1991 to May 1994, Lyme borreliosis was studied prospectively in 301 residents living on Aspö, a highly endemic area for the disease. The study included annual questionnaires and blood samples for serology. Immunoglobulin G (IgG) antibodies to Borrelia burgdorferi sensu lato were detected by enzyme-linked immunosorbent assay in 63/301 (21%) of the residents at the start of the study. Seropositivity rates increased with time, and 3 years later 101/301 (34%) were positive. A total of 34 individuals developed physician-verified manifestations of Lyme borreliosis during the study period. Nine individuals developed an erythema migrans, despite a previously treated Lyme borreliosis or pre-existing high levels of IgG antibodies to B. burgdorferi s.l.
1991年5月至1994年5月，对居住在阿斯波（该疾病的高流行地区）的301名居民进行了莱姆病螺旋体病的前瞻性研究。该研究包括年度问卷调查和用于血清学检测的血样。在研究开始时，通过酶联免疫吸附测定法在63/301（21%）的居民中检测到了抗广义伯氏疏螺旋体的免疫球蛋白G（IgG）抗体。血清阳性率随时间增加，3年后101/301（34%）呈阳性。在研究期间，共有34人出现了经医生证实的莱姆病螺旋体病表现。尽管先前已治疗过莱姆病螺旋体病或预先存在高水平的抗广义伯氏疏螺旋体IgG抗体，但仍有9人出现了游走性红斑。
