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人类ABO血型系统及其对某些传染病的抵抗力(预后)。

ABO system of blood groups in people and their resistance to certain infectious diseases (prognosis).

作者信息

Skripal' I G

机构信息

Institute of Microbiology and Virology, National Academy of Sciences, of Ukraine, Kyiv, Ukraine.

出版信息

Mikrobiol Z. 1996 Mar-Apr;58(2):102-8.

PMID:8953884
Abstract

Natural resistance to many infectious disease which to certain extent depends on the blood group of a person is inherent in people. As is known, human erythrocytes possess the surface antigens A, B, AB that determine the groups of blood. Blood group O erythrocytes do not possess these antigens but blood serum of such people have antibodies to A and B antigens. In people with blood group A there are antibodies to antigen B and vice versa. Human blood of AB group does not contain antibodies to erythrocyte antigens of other blood groups. This determines natural resistance of people to many infectious diseases whose agents have antigens on the surface of their cells that are similar to antigens of one or another group of blood. Thus antigens similar to those of blood group A erythrocytes are localized on the agents' cells, such agents are neutralized by natural antibodies of blood groups O and B. When antigens similar to those of blood group B erythrocytes are localized on the agents' cells, that is the obstacle for them when affecting people with blood group A and B whose serum includes a lot of antibodies to these antigens. Only people with blood group AB are most sensitive to infectious diseases which agents carry antigens A, B or both A and B on their cells, since blood of such people does not contain the corresponding natural antibodies. To illustrate the above said the author gives a prognosis of possible affection of people by most pathogenic mycoplasmas whose cells possess antigens similar to those of erythrocytes of one or another blood group.

摘要

人类对许多传染病具有天然抵抗力,这种抵抗力在一定程度上取决于人的血型。众所周知,人类红细胞具有决定血型的表面抗原A、B、AB。O型血红细胞不具备这些抗原,但这类人的血清中有抗A和抗B抗原的抗体。A型血的人有抗B抗原的抗体,反之亦然。AB型血的人血清中不含有针对其他血型红细胞抗原的抗体。这决定了人类对许多传染病的天然抵抗力,这些传染病病原体的细胞表面抗原与某一种或另一种血型的抗原相似。因此,与A型血红细胞抗原相似的抗原存在于病原体细胞上时,这类病原体可被O型血和B型血的天然抗体中和。当与B型血红细胞抗原相似的抗原存在于病原体细胞上时,这对感染A型血和B型血的人构成障碍,因为他们的血清中含有大量针对这些抗原的抗体。只有AB型血的人对病原体细胞携带抗原A、B或同时携带A和B的传染病最为敏感,因为这类人的血液中不含有相应的天然抗体。为了说明上述情况,作者对最具致病性的支原体可能感染人群的情况进行了预测,这些支原体的细胞具有与某一种或另一种血型红细胞相似的抗原。

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