Grunfeld C, Pang M, Shigenaga J K, Jensen P, Lallone R, Friedman J, Feingold K R
Department of Medicine, University of California, San Francisco, USA.
J Clin Endocrinol Metab. 1996 Dec;81(12):4342-6. doi: 10.1210/jcem.81.12.8954039.
Leptin, a hormone that is secreted by adipose tissue in proportion to fat stores, regulates energy balance and appetite. Recently, tumor necrosis factor and interleukin-1, cytokines that regulate the host response to infection, have been shown to acutely increase leptin levels, raising the possibility that leptin could mediate the anorexia of some infections. We measured leptin levels in patients with the acquired immunodeficiency syndrome and found that leptin levels were not increased relative to body fat in patients who were anorectic, were losing weight, or had a history of weight loss. Furthermore, leptin levels were not increased during secondary infection, suggesting that elevations in leptin do not play a key role in the anorexia of infections associated with acquired immunodeficiency syndrome.
瘦素是一种由脂肪组织按脂肪储存比例分泌的激素，可调节能量平衡和食欲。最近，肿瘤坏死因子和白细胞介素 -1（调节宿主对感染反应的细胞因子）已被证明可急性升高瘦素水平，这增加了瘦素可能介导某些感染所致厌食症的可能性。我们测量了获得性免疫缺陷综合征患者的瘦素水平，发现厌食、体重减轻或有体重减轻病史的患者，其瘦素水平相对于体脂并未升高。此外，继发感染期间瘦素水平也未升高，这表明瘦素升高在与获得性免疫缺陷综合征相关的感染性厌食症中并不起关键作用。
