Seven Arzu, Güzel Savaş, Aslan Mahmure, Hamuryudan Vedat
Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey.
Rheumatol Int. 2009 May;29(7):743-7. doi: 10.1007/s00296-008-0764-8. Epub 2008 Nov 14.
This study was designed to investigate the serum and synovial fluid leptin levels, and inflammatory markers in rheumatoid arthritis (RA) patients. Serum and synovial fluid leptin levels were significantly higher (P > 0.05) in RA patients than control group; RA patients with moderate disease activity (DAS < 2.7) having significantly higher leptin levels (P > 0.05) than those with low disease activity (DAS < 2.7). Leukocytes and erythrocyte sedimentation rate (ESR) were found to be significantly higher in moderate disease activity RA group compared to low activity group (P > 0.05, P < 0.001, respectively). Serum leptin level is found to be independent of age and inflammatory markers. ESR is positively correlated with DAS activity and CRP values. Our finding of no correlation between leptin and BMI shows that regulation of leptinemia is complex, and leptin levels cannot be used to assess RA activity.
本研究旨在调查类风湿关节炎（RA）患者的血清和滑液瘦素水平以及炎症标志物。RA患者的血清和滑液瘦素水平显著高于对照组（P>0.05）；疾病活动度中等（DAS<2.7）的RA患者的瘦素水平显著高于疾病活动度低（DAS<2.7）的患者（P>0.05）。与低活动度组相比，中等疾病活动度RA组的白细胞和红细胞沉降率（ESR）显著更高（分别为P>0.05，P<0.001）。发现血清瘦素水平与年龄和炎症标志物无关。ESR与DAS活动度和CRP值呈正相关。我们发现瘦素与BMI之间无相关性，这表明瘦素血症的调节很复杂，且瘦素水平不能用于评估RA活动度。
