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铁人三项赛期间的免疫系统与血清谷氨酰胺

The immune system and serum glutamine during a triathlon.

作者信息

Rohde T, MacLean D A, Hartkopp A, Pedersen B K

机构信息

Copenhagen Muscle Research Centre, University Hospital, Department 7641, Denmark.

出版信息

Eur J Appl Physiol Occup Physiol. 1996;74(5):428-34. doi: 10.1007/BF02337723.

Abstract

This study examined the influence of a triathlon on the immune system and on serum amino acid concentrations. Eight male triathletes swam 2500 m, bicycled 81 km, and ran 19 km. The concentration of total serum amino acids decreased during the race, with the lowest values occurring 2 h postexercise. Similarly, serum glutamine concentration declined from 468 (SEM 24) (prerace) to 318 (SEM 20) mumol-1 (2 h postrace) and the natural killer (NK) and lymphokine activated killer (LAK) cell activities were suppressed 2 h postexercise (P < 0.05). Blood mononuclear cell proliferation decreased during exercise with the lowest value observed after running. The leucocyte concentration increased during and after exercise due to an increase in the concentration of neutrophils and monocytes. There was no significant change in lymphocyte concentration during or after the exercise. The plasma concentration of interleukin-6 did not change and the plasma concentration of interleukin-1 beta and tumor necrosis factor-alpha were below detection limits. The LAK cell cytotoxicity, but not NK cell activity or proliferative response, was significantly correlated with serum glutamine concentrations (r = 0.39, P < 0.01). This study confirms that prolonged endurance exercise results in changes in the cytotoxic function of the NK and LAK cells as well as the proliferative response. The time-course of changes in serum glutamine concentrations were best parallelled by changes in LAK cell activities.

摘要

本研究考察了铁人三项运动对免疫系统及血清氨基酸浓度的影响。八名男性铁人三项运动员分别进行了2500米游泳、81公里自行车骑行和19公里跑步。比赛过程中血清总氨基酸浓度下降,运动后2小时降至最低值。同样,血清谷氨酰胺浓度从赛前的468(标准误24)降至赛后2小时的318(标准误20)微摩尔/升,自然杀伤(NK)细胞和淋巴因子激活杀伤(LAK)细胞活性在运动后2小时受到抑制(P<0.05)。运动过程中血液单核细胞增殖减少,跑步后降至最低值。由于中性粒细胞和单核细胞浓度增加,运动期间及运动后白细胞浓度升高。运动期间及运动后淋巴细胞浓度无显著变化。白细胞介素-6的血浆浓度未改变,白细胞介素-1β和肿瘤坏死因子-α的血浆浓度低于检测限。LAK细胞的细胞毒性与血清谷氨酰胺浓度显著相关(r=0.39,P<0.01),而NK细胞活性或增殖反应与之无关。本研究证实,长时间耐力运动会导致NK细胞和LAK细胞的细胞毒性功能以及增殖反应发生变化。血清谷氨酰胺浓度变化的时间进程与LAK细胞活性变化最为平行。

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