Sun Y F, Tsai C J, Hsieh C C, Lau Y T
Foo Yin Junior College of Nursing and Medical Technology, Kaohsiung, R.O.C.
Chin J Physiol. 1996;39(3):177-81.
Abnormalities of erythrocyte cation transport systems including Li-Na countertransport have been described in uremic patients. Dialysis appears to eliminate the difference in some of the patients. We investigated the rate of Li-Na countertransport from erythrocytes of normal healthy subjects and uremic patients undergoing hemodialysis treatment. We found that erythrocytes from uremic patients exhibited a significantly elevated rate of Li-Na countertransport. Furthermore, urea (30 mM) did not affect the rate of Li-Na countertransport or the electrolyte contents for Li loaded erythrocytes. Our findings showed that while both plasma and urea concentration and erythrocyte Li-Na countertransport were elevated in uremic patients, urea was not the major cause of the enhanced activity of the transporter.
尿毒症患者存在包括锂-钠逆向转运在内的红细胞阳离子转运系统异常。透析似乎能消除部分患者的这种差异。我们研究了正常健康受试者以及接受血液透析治疗的尿毒症患者红细胞的锂-钠逆向转运速率。我们发现，尿毒症患者的红细胞表现出显著升高的锂-钠逆向转运速率。此外，尿素（30 mM）对锂负载红细胞的锂-钠逆向转运速率或电解质含量没有影响。我们的研究结果表明，虽然尿毒症患者的血浆和尿素浓度以及红细胞锂-钠逆向转运均升高，但尿素并非转运体活性增强的主要原因。
