Trelease R B, Park J
Department of Anatomy and Cell Biology, UCLA School of Medicine 90095, USA.
Comput Methods Programs Biomed. 1996 Nov;51(3):171-81. doi: 10.1016/s0169-2607(96)01768-3.
We present a general cell behavior modelling system for immune functions, based on qualitative process theory. Model system heuristics integrate known characteristics and processes of cells, pathogens, antibodies, antigens, and cytokines. The system generates qualitative simulations of primary immune responses to bacterial and viral infections. Model heuristics can be mapped to a free-running cellular automata-like simulation that demonstrates quantitative behaviors of actor populations. This system serves as a tool for testing assumptions about cellular functions in immunity, as well the basis for a qualitative discovery system that may infer new process heuristics based on evaluation of experimental data.
我们基于定性过程理论提出了一种用于免疫功能的通用细胞行为建模系统。模型系统启发式方法整合了细胞、病原体、抗体、抗原和细胞因子的已知特征及过程。该系统生成针对细菌和病毒感染的初次免疫反应的定性模拟。模型启发式方法可映射到一个类似自由运行细胞自动机的模拟中，该模拟展示了行为主体群体的定量行为。此系统可作为一种工具，用于检验关于免疫中细胞功能的假设，同时也是定性发现系统的基础，该发现系统可基于对实验数据的评估推断出新的过程启发式方法。
