Ruggiero C, Giacomini M, Rolfe P
Department of Communication, Computer & System Sciences, University of Genova, Italy.
Med Biol Eng Comput. 1999 Sep;37(5):659-66. doi: 10.1007/BF02513363.
An approach to modelling cytoskeletal function based on qualitative process theory and qualitative algebra is presented. A computer environment for qualitative modelling and simulation of physical systems, specifically oriented to the construction of biomedical knowledge bases, is used. The system that is being set up for the cytoskeleton is intended to serve as a tool for testing assumptions about cytoskeletal function, for the evaluation of experimental data and for planning experimental work. The aspects of cytoskeletal function that have been modelled so far are focal adhesion and the reorganisation of the vascular endothelial cell cytoskeleton in response to fluid-imposed shear stress. Starting from a natural language description, the subsequent levels of analysis leading to the formal structural description and the resulting implementation for these aspects within the development environment are presented.
本文提出了一种基于定性过程理论和定性代数对细胞骨架功能进行建模的方法。使用了一个专门用于构建生物医学知识库的物理系统定性建模与仿真的计算机环境。为细胞骨架建立的系统旨在作为一种工具，用于检验关于细胞骨架功能的假设、评估实验数据以及规划实验工作。目前已建模的细胞骨架功能方面包括粘着斑以及血管内皮细胞骨架对流体施加的剪切应力的重组。从自然语言描述开始，展示了后续的分析层次，这些层次导致了形式结构描述以及在开发环境中针对这些方面的最终实现。
