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茶儿茶素、红茶提取物和乌龙茶提取物对大鼠肝癌发生的抑制作用。

Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.

作者信息

Matsumoto N, Kohri T, Okushio K, Hara Y

机构信息

Food Research Laboratories, Mitsui Norin Co., Ltd., Shizuoka, Japan.

出版信息

Jpn J Cancer Res. 1996 Oct;87(10):1034-8. doi: 10.1111/j.1349-7006.1996.tb03106.x.

DOI:10.1111/j.1349-7006.1996.tb03106.x
PMID:8957060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5920992/
Abstract

Inhibitory effects of individual tea catechins ((--)-epicatechin, (--)-epigallocatechin, (--)-epicatechin gallate, (--)-epigallocatechin gallate), black tea extract and oolong tea extract on hepatocarcinogenesis were investigated. Male F344 rats received a single dose of diethylnitrosamine (200 mg/kg, i.p.), and thereafter phenobarbital (0.05%) was administered in the drinking water for a period of 6 weeks. Tea catechins, black tea extract or oolong tea extract were given during the entire experimental period, during only the initiation period or during only the promotion period. All four tea catechins, black tea extract and oolong tea extract (0.05 or 0.1%) significantly decreased the number and area of preneoplastic glutathione S-transferase placental form-positive foci in the liver. These results suggest that tea catechins, black tea extract and oolong tea extract have a chemopreventive action against hepatocarcinogenesis.

摘要

研究了单一茶儿茶素（（-）-表儿茶素、（-）-表没食子儿茶素、（-）-表儿茶素没食子酸酯、（-）-表没食子儿茶素没食子酸酯）、红茶提取物和乌龙茶提取物对肝癌发生的抑制作用。雄性F344大鼠接受单次剂量的二乙基亚硝胺（200mg/kg，腹腔注射），之后在饮用水中给予苯巴比妥（0.05%），持续6周。茶儿茶素、红茶提取物或乌龙茶提取物在整个实验期间、仅在启动期或仅在促进期给予。所有四种茶儿茶素、红茶提取物和乌龙茶提取物（0.05%或0.1%）均显著减少了肝脏中癌前谷胱甘肽S-转移酶胎盘型阳性灶的数量和面积。这些结果表明，茶儿茶素、红茶提取物和乌龙茶提取物对肝癌发生具有化学预防作用。

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Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.一种食物源性致癌物2-氨基-3,8-二甲基咪唑[4,5-f]喹喔啉在低剂量水平下对大鼠肝脏中8-羟基鸟嘌呤和癌前病灶的剂量依赖性诱导作用。
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