Ohno Y, Wakai K, Genka K, Ohmine K, Kawamura T, Tamakoshi A, Aoki R, Senda M, Hayashi Y, Nagao K
Department of Preventive Medicine, Nagoya University School of Medicine.
Jpn J Cancer Res. 1995 Nov;86(11):1027-34. doi: 10.1111/j.1349-7006.1995.tb03016.x.
To disclose the relationship between tea consumption and lung cancer risk, we analyzed the data from a case-control study conducted in Okinawa, Japan from 1988 to 1991. The analysis, based on 333 cases and 666 age-, sex- and residence-matched controls, provided the following major findings. (a) The greater the intake of Okinawa tea (a partially fermented tea), the smaller the risk, particularly in women. For females, the odds ratios (and 95% confidence intervals) for those who consumed 1-4, 5-9, and 10 cups or more of Okinawan tea every day, relative to non-daily tea drinkers, were 0.77 (0.28-2.13), 0.77 (0.26-2.25) and 0.38 (0.12-1.18), respectively (trend: P = 0.032). The corresponding odds ratios for males were 0.85 (0.45-1.55), 0.85 (0.45-1.56) and 0.57 (0.31-1.06) (trend: P = 0.053). (b) The risk reduction by Okinawan tea consumption was detected mainly in squamous cell carcinoma. Daily tea consumption significantly decreased the risk of squamous cell carcinoma in males and females, the odds ratios being 0.50 (95% confidence interval 0.27-0.93) and 0.08 (0.01-0.68), respectively. These findings suggest a protective effect of tea consumption against lung cancer in humans.
为了揭示饮茶与肺癌风险之间的关系，我们分析了1988年至1991年在日本冲绳进行的一项病例对照研究的数据。该分析基于333例病例和666名年龄、性别及居住地匹配的对照，得出了以下主要结果。(a) 冲绳茶（一种半发酵茶）的摄入量越高，风险越小，尤其是在女性中。对于女性，每天饮用1 - 4杯、5 - 9杯以及10杯或更多冲绳茶的人群相对于不每天饮茶者的比值比（及95%置信区间）分别为0.77（0.28 - 2.13）、0.77（0.26 - 2.25）和0.38（0.12 - 1.18）（趋势：P = 0.032）。男性的相应比值比分别为0.85（0.45 - 1.55）、0.85（0.45 - 1.56）和0.57（0.31 - 1.06）（趋势：P = 0.053）。(b) 饮用冲绳茶降低风险主要体现在鳞状细胞癌方面。每日饮茶显著降低了男性和女性患鳞状细胞癌的风险，比值比分别为0.50（95%置信区间0.27 - 0.93）和0.08（0.01 - 0.68）。这些发现表明饮茶对人类肺癌具有保护作用。
