Lin N, Eisen S A, Scherrer J F, Goldberg J, True W R, Lyons M J, Tsuang M T
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Drug Alcohol Depend. 1996 Dec 2;43(1-2):49-55. doi: 10.1016/s0376-8716(96)01287-2.
The co-occurrence of major depression (MD) with alcohol and illicit substance abuse/dependence (A/D) has been repeatedly observed. However, prior research has been unable to determine whether or not the co-occurrence is a result of familial vulnerability or non-familial influences. The present study examines the association of the lifetime diagnosis of MD with alcohol, cannabis, amphetamine, cocaine, and sedative A/D (DSM-III-R criteria) before and after controlling for familial factors in a non-clinical sample of 1874 middle aged, monozygotic male twin pairs. A lifetime diagnosis of MD was significantly associated with lifetime diagnosis of alcohol and illicit substance A/D prior to accounting for familial factors (odds ratios: 1.8-4.5). After employing a co-twin analytical technique to control for familial factors, a lifetime diagnosis of MD remained significantly associated only with lifetime diagnoses of cannabis, amphetamine and sedative A/D (odds ratios: 2.3-10.9). These results suggest that the association between MD and alcohol A/D is influenced by familial factors. In contrast, the association between MD and illicit substances of A/D is largely explained by non-familial factors.
重度抑郁症（MD）与酒精及非法药物滥用/依赖（A/D）同时出现的情况已被反复观察到。然而，先前的研究无法确定这种同时出现是家族易感性还是非家族性影响的结果。本研究在1874对中年同卵男性双胞胎的非临床样本中，在控制家族因素前后，考察了MD的终生诊断与酒精、大麻、安非他明、可卡因和镇静剂A/D（DSM-III-R标准）之间的关联。在考虑家族因素之前，MD的终生诊断与酒精和非法药物A/D的终生诊断显著相关（优势比：1.8 - 4.5）。在采用同卵双胞胎分析技术控制家族因素后，MD的终生诊断仅与大麻、安非他明和镇静剂A/D的终生诊断仍显著相关（优势比：2.3 - 10.9）。这些结果表明，MD与酒精A/D之间的关联受家族因素影响。相比之下，MD与非法药物A/D之间的关联很大程度上由非家族因素解释。
