Pedersen A
Department of Oral Medicine and Surgery, University Hospital of Copenhagen (Rigshospitalet), Denmark.
Oral Dis. 1996 Jun;2(2):125-8. doi: 10.1111/j.1601-0825.1996.tb00212.x.
To investigate any possible association between oral lichen planus (OLP) and the humoral immune response to Epstein-Barr virus (EBV).
The population consisted of 22 patients with histologically verified OLP and 22 healthy sex- and age-matched controls without any oral mucosal diseases. Specific serum IgG antibodies (Ab) towards EBV early antigen (EA) and nuclear antigen-I (EBNA) and IgM Ab towards EBV EA were determined by ELISA.
The optometric density (OD) IgG anti-EA Ab levels were significantly higher in OLP patients than in controls and a significantly negative correlation between duration of symptoms from OLP and IgG anti-EA OD Ab values was demonstrated. IgM anti-EA and IgG anti-EBNA OD Ab levels were not significantly different between the two groups.
The hypothesis of any possible association between EBV and OLP has never been tested but the present results seem to lend support for an aberration in the humoral response to EBV in OLP patients.
研究口腔扁平苔藓（OLP）与针对爱泼斯坦-巴尔病毒（EBV）的体液免疫反应之间的任何可能关联。
研究对象包括22例经组织学证实的OLP患者以及22名年龄和性别匹配、无任何口腔黏膜疾病的健康对照者。采用酶联免疫吸附测定法（ELISA）检测血清中针对EBV早期抗原（EA）和核抗原-I（EBNA）的特异性IgG抗体（Ab）以及针对EBV EA的IgM Ab。
OLP患者中抗EA IgG抗体的光密度（OD）水平显著高于对照组，且OLP症状持续时间与抗EA IgG OD抗体值之间存在显著负相关。两组之间抗EA IgM和抗EBNA IgG OD抗体水平无显著差异。
EBV与OLP之间任何可能关联的假说此前从未得到验证，但目前的结果似乎支持OLP患者针对EBV的体液反应存在异常这一观点。
