Schor S L, Ellis I, Irwin C R, Banyard J, Seneviratne K, Dolman C, Gilbert A D, Chisholm D M
Department of Dental Surgery and Periodontology, Dental School, University of Dundee, UK.
Oral Dis. 1996 Jun;2(2):155-66. doi: 10.1111/j.1601-0825.1996.tb00217.x.
Wound healing in the adult is commonly compromised by excessive scar formation. In contrast, fetal wound healing is a regenerative process characterised by the conspicuous absence of scarring. Available evidence suggests that phenotypic differences between fetal and adult fibroblasts are important determinants of these distinct modes of tissue repair. In this context, a number of groups (including our own) have documented differences between fetal and adult fibroblasts with respect to such potentially relevant characteristics as migratory activity, motogenic response to cytokines and the synthesis of motility factors, cytokines and matrix macromolecules. The oral mucosa appears to be a privileged site in the adult in that it continues to display a fetal-like mode of wound healing. Data are presented in this review indicating that a subpopulation of gingival fibroblasts expresses several 'fetal-like' phenotypic characteristics. These observations are discussed in terms of both the continued expression of a fetal-like mode of wound healing in the oral mucosa and the possible differential involvement of distinct fibroblast subpopulations in the progression of periodontal disease.
成人伤口愈合通常会因过度形成瘢痕而受到影响。相比之下，胎儿伤口愈合是一个再生过程，其特点是明显没有瘢痕形成。现有证据表明，胎儿和成纤维细胞之间的表型差异是这些不同组织修复模式的重要决定因素。在这种情况下，许多研究小组（包括我们自己的小组）已经记录了胎儿和成纤维细胞在迁移活性、对细胞因子的促运动反应以及运动因子、细胞因子和基质大分子合成等潜在相关特征方面的差异。口腔黏膜在成人中似乎是一个特殊部位，因为它继续表现出类似胎儿的伤口愈合模式。本综述提供的数据表明，牙龈成纤维细胞亚群表达几种“胎儿样”表型特征。这些观察结果将从口腔黏膜中持续表达类似胎儿的伤口愈合模式以及不同成纤维细胞亚群在牙周病进展中可能的不同参与情况两个方面进行讨论。
