Häkkinen Lari, Larjava Hannu, Fournier Benjamin P J
Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Cytotherapy. 2014 Sep;16(9):1171-86. doi: 10.1016/j.jcyt.2014.04.004. Epub 2014 Jun 13.
Gingiva of the oral mucosa provides a practical source to isolate fibroblasts for therapeutic purposes because the tissue is easily accessible, tissue discards are common during routine clinical procedures and wound healing after biopsy is fast and results in complete wound regeneration with very little morbidity or scarring. In addition, gingival fibroblasts have unique traits, including neural crest origin, distinct gene expression and synthetic properties and potent immunomodulatory functions. These characteristics may provide advantages for certain therapeutic approaches over other more commonly used cells, including skin fibroblasts, both in intraoral and extra-oral sites. However, identity and phenotype of gingival fibroblasts, like other fibroblasts, are still not completely understood. Gingival fibroblasts are phenotypically heterogeneous, and these…fibroblast subpopulations may play different roles in tissue maintenance, regeneration and pathologies. The purpose of this review is to summarize what is currently known about gingival fibroblasts, their distinct potential for tissue regeneration and their potential therapeutic uses in the future.
口腔黏膜的牙龈为分离成纤维细胞用于治疗目的提供了一个实用的来源，因为该组织易于获取，在常规临床操作中组织丢弃很常见，活检后的伤口愈合迅速，且能实现完全的伤口再生，几乎没有发病率或疤痕。此外，牙龈成纤维细胞具有独特的特性，包括神经嵴起源、独特的基因表达和合成特性以及强大的免疫调节功能。与其他更常用的细胞（包括皮肤成纤维细胞）相比，这些特性可能为某些治疗方法在口腔内和口腔外部位提供优势。然而，与其他成纤维细胞一样，牙龈成纤维细胞的身份和表型仍未完全明确。牙龈成纤维细胞在表型上是异质的，这些成纤维细胞亚群可能在组织维持、再生和病理过程中发挥不同的作用。本综述的目的是总结目前关于牙龈成纤维细胞的已知信息、它们在组织再生方面的独特潜力以及它们未来潜在的治疗用途。
