Seegal R F
New York State Department of Health, Wadsworth Center for Laboratories and Research, Albany 12201-0509, USA.
Crit Rev Toxicol. 1996 Nov;26(6):709-37. doi: 10.3109/10408449609037481.
The purpose of this review is to provide a selective, but critical, assessment of important findings derived from both epidemiological and laboratory studies suggesting that: (1) exposure to polychlorinated biphenyls (PCBs) and related halogenated aromatic hydrocarbons induces significant neurological and behavioral dysfunctions in humans and laboratory animals, particularly following exposure during gestation and lactation; (2) the neurochemical actions of PCBs depend on their structure and the developmental status of the animal at the time of exposure; and (3) the mechanisms responsible for these changes may involve alterations in basic cellular signaling processes and endocrine function that influence the synthesis and activity of important central nervous system neurotransmitters, the organization of the developing brain, and the behavioral responses to these environmental contaminants.
本综述的目的是对流行病学和实验室研究的重要发现进行有选择性但批判性的评估，这些研究表明：（1）接触多氯联苯（PCBs）及相关卤代芳烃会在人类和实验动物中引发显著的神经和行为功能障碍，尤其是在孕期和哺乳期接触之后；（2）多氯联苯的神经化学作用取决于其结构以及动物在接触时的发育状态；（3）导致这些变化的机制可能涉及基本细胞信号传导过程和内分泌功能的改变，这些改变会影响重要中枢神经系统神经递质的合成和活性、发育中大脑的组织以及对这些环境污染物的行为反应。
