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A型肉毒杆菌神经毒素对腰段单突触反射逆向刺激抑制作用的影响

The action of botulinum A neurotoxin on the inhibition by antidromic stimulation of the lumbar monosynaptic reflex.

作者信息

Wiegand H, Wellhöner H H

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1977 Jul;298(3):235-8. doi: 10.1007/BF00500893.

DOI:10.1007/BF00500893
PMID:895899
Abstract
  1. Botulinum toxin type A was injected into gastrocnemius muscles of cats and 2 days later its action on the monosynaptic gastrocnemius reflex and on the recurrent inhibition was investigated. 2. In early local botulism, no significant change in the monosynaptic gastrocnemius reflex was observed. 3. The inhibition by antidromic stimulation of the monosynaptic gastrocnemius reflex was significantly reduced. 4. During the early phases of local botulism an action of botulinum toxin on parts of the soma membrane of the alpha-motoneuron is suggested.
摘要
  1. 将A型肉毒杆菌毒素注射到猫的腓肠肌中，两天后研究其对单突触腓肠肌反射和回返抑制的作用。2. 在早期局部肉毒中毒时，未观察到单突触腓肠肌反射有明显变化。3. 由逆向刺激引起的单突触腓肠肌反射抑制作用显著降低。4. 在局部肉毒中毒的早期阶段，提示肉毒杆菌毒素对α运动神经元胞体膜的某些部分有作用。

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本文引用的文献

1
Distribution of recurrent inhibition among motoneurones.运动神经元间回返抑制的分布
J Physiol. 1961 Dec;159(3):479-99. doi: 10.1113/jphysiol.1961.sp006822.
2
Proceedings: Type A botulinum toxin in cats: neural ascent and action on spinal cord reflexes.论文集：猫体内的A型肉毒杆菌毒素：神经上行及对脊髓反射的作用
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R106.
3
125I-labeled neurotoxin from Clostridium botulinum A: preparation, binding to synaptosomes and ascent to the spinal cord.来自肉毒杆菌A的125I标记神经毒素：制备、与突触体的结合及向脊髓的上行
Toxicon. 2018 Jun 1;147:73-76. doi: 10.1016/j.toxicon.2017.08.011. Epub 2017 Aug 11.
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Toxin yet not toxic: Botulinum toxin in dentistry.毒素却无毒：牙科中的肉毒杆菌毒素
Saudi Dent J. 2016 Apr;28(2):63-9. doi: 10.1016/j.sdentj.2015.08.002. Epub 2015 Dec 21.
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Spinal plasticity in stroke patients after botulinum neurotoxin A injection in ankle plantar flexors.肉毒杆菌神经毒素A注射踝关节跖屈肌后中风患者的脊髓可塑性
Physiol Rep. 2013 Nov;1(6):e00173. doi: 10.1002/phy2.173. Epub 2013 Nov 26.
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Beyond muscular effects: depression of spinal recurrent inhibition after botulinum neurotoxin A.超越肌肉效应：肉毒杆菌神经毒素 A 后脊髓反射性抑制的抑制。
J Physiol. 2013 Feb 15;591(4):1017-29. doi: 10.1113/jphysiol.2012.239178. Epub 2012 Oct 8.
7
[Long-term treatment of phantom- and stump pain with Botulinum toxin type A over 12 months. A first clinical observation].[A型肉毒杆菌毒素对幻肢痛和残端痛进行超过12个月的长期治疗。首次临床观察]
Nervenarzt. 2004 Apr;75(4):336-40. doi: 10.1007/s00115-003-1657-4.
8
Is there a role for botulinum toxin in the treatment of migraine?肉毒杆菌毒素在偏头痛治疗中是否有作用？
Curr Pain Headache Rep. 2003 Jun;7(3):229-34. doi: 10.1007/s11916-003-0078-1.
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Preventative treatment for migraine and tension-type headaches : do drugs having effects on muscle spasm and tone have a role?偏头痛和紧张型头痛的预防性治疗：对肌肉痉挛和紧张度有作用的药物是否起作用？
CNS Drugs. 2003;17(6):373-81. doi: 10.2165/00023210-200317060-00001.
10
Mechanism of Botulinum Toxin in the Relief of Chronic Pain.肉毒杆菌毒素缓解慢性疼痛的机制。
Curr Rev Pain. 1999;3(6):427-431. doi: 10.1007/s11916-999-0069-y.
Naunyn Schmiedebergs Arch Pharmacol. 1974;281(1):47-56. doi: 10.1007/BF00500611.
4
The action of tetanus toxin on preganglionic sympathetic reflex discharges.破伤风毒素对节前交感神经反射放电的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1973;276(3-4):437-45. doi: 10.1007/BF00499896.
5
Direct evidence for the specific fixation of Cl. botulinum A neurotoxin to brain matter.肉毒杆菌A神经毒素与脑物质特异性结合的直接证据。
Naunyn Schmiedebergs Arch Pharmacol. 1975;287(1):97-106. doi: 10.1007/BF00632641.
6
Binding of botulinum neurotoxin to the synaptosome fraction of rat brain.
Naunyn Schmiedebergs Arch Pharmacol. 1976 Nov;295(2):171-5. doi: 10.1007/BF00499451.
7
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