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The cytokine network in rheumatoid arthritis: definition of TNF alpha as a therapeutic target.

作者信息

Feldmann M

机构信息

Cytokine and Immunology Division, Kennedy Institute of Rheumatology.

出版信息

J R Coll Physicians Lond. 1996 Nov-Dec;30(6):560-70.

PMID:8961212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5401498/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/d226b267247b/jrcollphyslond90380-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/c365ccdde284/jrcollphyslond90380-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/abfe2c4117de/jrcollphyslond90380-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/c78c0340b5a9/jrcollphyslond90380-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/e7f5a7829a20/jrcollphyslond90380-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/7d1f6b45f60a/jrcollphyslond90380-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/4311f0f8bb48/jrcollphyslond90380-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/eb9f96de9f6e/jrcollphyslond90380-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/d226b267247b/jrcollphyslond90380-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/c365ccdde284/jrcollphyslond90380-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/abfe2c4117de/jrcollphyslond90380-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/c78c0340b5a9/jrcollphyslond90380-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/e7f5a7829a20/jrcollphyslond90380-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/7d1f6b45f60a/jrcollphyslond90380-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/4311f0f8bb48/jrcollphyslond90380-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/eb9f96de9f6e/jrcollphyslond90380-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a9/5401498/d226b267247b/jrcollphyslond90380-0080-a.jpg

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本文引用的文献

1
Cytokines in autoimmunity.自身免疫中的细胞因子。
Curr Opin Immunol. 1996 Dec;8(6):872-7. doi: 10.1016/s0952-7915(96)80018-5.
2
The role of cytokines in rheumatoid arthritis. The Croonian Lecture 1995.细胞因子在类风湿关节炎中的作用。1995年克罗尼安讲座
J R Coll Physicians Lond. 1996 Jul-Aug;30(4):344-51.
3
Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.类风湿性滑膜膜细胞培养中促炎细胞因子释放的调节。单克隆抗TNF-α抗体与白细胞介素-1受体拮抗剂的比较。
Identification of Novel Single Chain Fragment Variable Antibodies Against TNF-α Using Phage Display Technology.
利用噬菌体展示技术鉴定新型抗TNF-α单链抗体可变区片段
Adv Pharm Bull. 2015 Dec;5(Suppl 1):661-6. doi: 10.15171/apb.2015.090. Epub 2015 Dec 31.
4
Effects of Antitumor Necrosis Factor Therapy on Osteoprotegerin, Neopterin, and sRANKL Concentrations in Patients with Rheumatoid Arthritis.抗肿瘤坏死因子疗法对类风湿关节炎患者骨保护素、新蝶呤和可溶性核因子κB受体活化因子配体浓度的影响。
Dis Markers. 2015;2015:276969. doi: 10.1155/2015/276969. Epub 2015 Oct 21.
5
Associations of Circulating Soluble Tumor Necrosis Factor-α Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection.在感染HIV或有感染HIV高风险的注射吸毒者老龄队列中，循环可溶性肿瘤坏死因子-α受体1和2与白细胞介素-6水平的关联。
AIDS Res Hum Retroviruses. 2015 Dec;31(12):1257-64. doi: 10.1089/AID.2015.0134. Epub 2015 Oct 13.
6
Effect and mechanism of AR-6 in experimental rheumatoid arthritis.AR-6 在实验性类风湿关节炎中的作用及机制。
Clin Exp Med. 2010 Jun;10(2):113-21. doi: 10.1007/s10238-009-0075-8. Epub 2009 Oct 20.
7
Adenosine and cytokine levels following treatment of rheumatoid arthritis with dipyridamole.双嘧达莫治疗类风湿关节炎后的腺苷和细胞因子水平
Rheumatol Int. 2006 Nov;27(1):11-7. doi: 10.1007/s00296-006-0212-6. Epub 2006 Sep 20.
Eur Cytokine Netw. 1995 Jul-Dec;6(4):225-30.
4
Role of cytokines in rheumatoid arthritis.细胞因子在类风湿关节炎中的作用。
Annu Rev Immunol. 1996;14:397-440. doi: 10.1146/annurev.immunol.14.1.397.
5
Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis.类风湿关节炎中抗肿瘤坏死因子α单克隆抗体对血管内皮的失活作用
Arthritis Rheum. 1996 Jul;39(7):1082-91. doi: 10.1002/art.1780390703.
6
Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.平衡免疫与耐受：删除和调整淋巴细胞库
Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2264-71. doi: 10.1073/pnas.93.6.2264.
7
Human self-reactive T cell clones expressing identical T cell receptor beta chains differ in their ability to recognize a cryptic self-epitope.表达相同T细胞受体β链的人类自身反应性T细胞克隆在识别隐蔽自身表位的能力上存在差异。
J Exp Med. 1996 Feb 1;183(2):349-58. doi: 10.1084/jem.183.2.349.
8
Rheumatoid arthritis.类风湿关节炎
Cell. 1996 May 3;85(3):307-10. doi: 10.1016/s0092-8674(00)81109-5.
9
Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system.多发性硬化症：针对中枢神经系统中髓鞘的协同免疫攻击。
Cell. 1996 May 3;85(3):299-302. doi: 10.1016/s0092-8674(00)81107-1.
10
Insulin-dependent diabetes mellitus.胰岛素依赖型糖尿病
Cell. 1996 May 3;85(3):291-7. doi: 10.1016/s0092-8674(00)81106-x.