Gross P A, Denning C R, Gaerlan P F, Bonelli J, Bernius M, Dran S, Monk G, Vassallo M, Quinnan G V, Levandowski R, Cataruozolo P E, Wallenstein S
Department of Internal Medicine, Hackensack University Medical Center, NJ, USA.
Vaccine. 1996 Sep;14(13):1280-4. doi: 10.1016/s0264-410x(96)00004-7.
To determine the effect of repeated annual influenza immunization on the host's serum antibody.
Ten year observational study with cohort design.
Cystic Fibrosis Center at St. Vincent's Hospital and Medical Center, New York City, NY.
Thirty-eight children and young adults with cystic fibrosis (CF).
Serum hemagglutination inhibition (HI) antibody titers were determined at the time of vaccination and 4 weeks later each year in the fall before the influenza epidemic. Shwachman scores were determined each year.
While the pre-vaccination and post-vaccination geometric mean serum HI antibody titers varied from year to year, no upward or downward trend was evident over the 10 year period. The reciprocal of the post-vaccination geometric mean HI titers ranged annually from 32 to 74 for the influenza A (H3N2) vaccine strains, from 53 to 133 for the influenza A (H1N1) strains, and from 18 to 174 for influenza B strains. In addition, the majority of vaccinees had a presumably protective post-vaccination serum HI titer > or = 1:40 each year for all three vaccine strains. The initial mean Shwachman score of the group was 77. The final score of 76 after 10 years was not significantly different.
Annual influenza vaccination appears to regularly induce presumably protective serum antibody levels in most CF children and young adults studied over a 10 year period.
确定每年重复进行流感免疫接种对宿主血清抗体的影响。
采用队列设计的十年观察性研究。
纽约市圣文森特医院及医疗中心囊性纤维化中心。
38名患有囊性纤维化（CF）的儿童和青年。
在接种疫苗时以及每年秋季流感流行前4周测定血清血凝抑制（HI）抗体滴度。每年测定施瓦赫曼评分。
虽然接种疫苗前和接种疫苗后的几何平均血清HI抗体滴度逐年变化，但在10年期间没有明显的上升或下降趋势。对于甲型（H3N2）流感疫苗株，接种疫苗后的几何平均HI滴度的倒数每年在32至74之间；对于甲型（H1N1）流感毒株，在53至133之间；对于乙型流感毒株，在18至174之间。此外，大多数接种者每年接种疫苗后的血清HI滴度均≥1:40，这可能具有保护作用。该组的初始平均施瓦赫曼评分为77分。10年后的最终评分为76分，无显著差异。
在为期10年的研究中，每年进行流感疫苗接种似乎能定期在大多数CF儿童和青年中诱导出可能具有保护作用的血清抗体水平。
