Cannon C R
J Miss State Med Assoc. 1996 Nov;37(11):817-21.
Several studies have indicated that antibiotics given for 5-7 days post-tonsillectomy are beneficial. A prospective double blind randomized study was undertaken to evaluate the efficacy of a long-acting antibiotic (Cefonicid) given prophylactically at the time of tonsillectomy. Dependent variables were percent weight loss, number of doses of pain medications required postoperatively, the number of days required to resume a normal diet, and return to work. The results of all independent tests indicated that there were no statistically significant differences between the Cefonicid group and the placebo group. The results of this study indicate that single dose prophylactic application of Cefonicid is not effective in adults undergoing tonsillectomy.
多项研究表明，扁桃体切除术后使用5至7天抗生素是有益的。进行了一项前瞻性双盲随机研究，以评估在扁桃体切除时预防性使用长效抗生素（头孢尼西）的疗效。因变量包括体重减轻百分比、术后所需止痛药物剂量、恢复正常饮食所需天数以及重返工作岗位的情况。所有独立测试结果表明，头孢尼西组和安慰剂组之间没有统计学上的显著差异。这项研究的结果表明，单剂量预防性应用头孢尼西对接受扁桃体切除术的成年人无效。
