ENT Department, Jordan University Hospital, Faculty of Medicine, University of Jordan, PO Box 13046, Amman, Jordan.
Eur Arch Otorhinolaryngol. 2013 Jan;270(1):367-70. doi: 10.1007/s00405-012-2119-z. Epub 2012 Aug 3.
The objectives are to assess the efficacy of antibiotics in reducing post-tonsillectomy morbidities in children. This is a clinical trial study that was undertaken at the Jordan University Hospital during the period from June 2008 to July 2009. All patients undergoing tonsillectomy were randomly divided into two matched groups on alternating basis: group A included patients who received antibiotics (amoxicillin with clavulanic acid) for 5 days in the post-tonsillectomy period and group B included patients who received none. The two groups were compared with respect to fever, secondary bleeding, throat pain, and the time to resume to normal diet. Bleeding was more common in group A (5.5 %) than in group B (2 %). The average duration of throat pain was 4.2 days in group A, while it was 3.9 days in group B. The average time to resume normal diet was 5.7 days in group A, whereas it was 5.3 days in group B. Fever was noted in 17 (31 %) patients from group A, while it was observed in 15 (30 %) patients from group B. The use of antibiotics in the post-tonsillectomy period does not reduce post-operative morbidity in children and therefore it is advised to use antibiotics on an individual basis rather than routinely for patients undergoing tonsillectomy.
目的在于评估抗生素在降低儿童扁桃体切除术后并发症方面的疗效。这是一项于 2008 年 6 月至 2009 年 7 月在约旦大学医院开展的临床试验研究。所有接受扁桃体切除术的患者均采用交替分组的方式随机分为两组：A 组患者术后接受 5 天的抗生素（阿莫西林克拉维酸）治疗，B 组患者则不接受抗生素治疗。比较两组患者的发热、继发性出血、咽喉疼痛以及恢复正常饮食的时间。A 组（5.5%）的出血发生率高于 B 组（2%）。A 组患者的咽喉疼痛平均持续时间为 4.2 天，B 组为 3.9 天。A 组患者恢复正常饮食的平均时间为 5.7 天，B 组为 5.3 天。A 组有 17 名（31%）患者出现发热，B 组有 15 名（30%）患者出现发热。扁桃体切除术后使用抗生素并不能降低儿童的术后发病率，因此建议根据患者个体情况使用抗生素，而不是常规用于扁桃体切除术患者。
