Niebauer J, Cooke J P
Section of Vascular Medicine, Stanford University, California 94305-5246, USA.
J Am Coll Cardiol. 1996 Dec;28(7):1652-60. doi: 10.1016/S0735-1097(96)00393-2.
Experimental, epidemiologic and clinical studies have provided strong evidence that physical exercise has beneficial effects on multiple physiological variables affecting cardiovascular health (lipoprotein levels, rest blood pressure and heart rate, carbohydrate tolerance, neurohormonal activity). Regular exercise has been shown to slow the progression of cardiovascular disease and to reduce cardiovascular morbidity and mortality. More recently, exercise-induced increases in blood flow and shear stress have been observed to enhance vascular function and structure. By increasing the release of nitric oxide and prostacyclin, shear stress augments endothelium-dependent vasodilation and inhibits multiple processes involved in atherogenesis and restenosis. In this review we discuss the underlying mechanisms by which exercise-induced blood flow and shear stress exert their salutary effects on cardiovascular remodeling.
实验、流行病学和临床研究提供了强有力的证据，表明体育锻炼对影响心血管健康的多个生理变量（脂蛋白水平、静息血压和心率、碳水化合物耐受性、神经激素活性）具有有益作用。有研究表明，规律运动可减缓心血管疾病的进展，并降低心血管发病率和死亡率。最近，人们观察到运动引起的血流增加和剪切应力可增强血管功能和结构。通过增加一氧化氮和前列环素的释放，剪切应力可增强内皮依赖性血管舒张，并抑制参与动脉粥样硬化和再狭窄的多个过程。在这篇综述中，我们讨论了运动引起的血流和剪切应力对心血管重塑产生有益影响的潜在机制。
