Kato M, Mizuguchi M, Sakuta R, Takashima S
Department of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry, Tokyo, Japan.
Pediatr Neurol. 1996 May;14(4):335-8. doi: 10.1016/0887-8994(96)00057-4.
We morphometrically measured the cut surface of the cerebral hemisphere and localized epidermal growth factor (EGF)-like immunoreactivity in 4 patients with hemimegalencephaly. On the affected side, the area of cerebral white matter was more than twice as large as that on the unaffected side, while the area of the cerebral cortex on the affected side was relatively small. EGF-like immunoreactivity was demonstrated in cortical neurons (4 of 4 patients) and glial cells (3 of 4 patients), notably in astrocytes. Significant enlargement of the cerebral white matter compared to the cerebral cortex and the expression of EGF-like molecules in astrocytes suggest excessive proliferation in the white matter with hemimegalencephaly and the possible relevance of EGF to these events.
我们对4例半侧巨脑症患者的大脑半球切面进行了形态测量，并对表皮生长因子（EGF）样免疫反应性进行了定位。在患侧，脑白质面积比未患侧大两倍多，而患侧大脑皮质面积相对较小。在皮质神经元（4例患者中的4例）和神经胶质细胞（4例患者中的3例）中证实了EGF样免疫反应性，尤其是在星形胶质细胞中。与大脑皮质相比，脑白质显著增大以及星形胶质细胞中EGF样分子的表达表明，半侧巨脑症患者白质过度增殖，且EGF可能与这些事件相关。
