Reynaert H, Fernandes E, Bourgain C, Smekens L, Devis G
Department of Gastroenterology and Hepatology, University Hospital AZ-VUB, Brussels, Belgium.
J Gastroenterol. 1995 Dec;30(6):775-8. doi: 10.1007/BF02349646.
Two patients who developed gastric giardiasis after 2 weeks of treatment with omeprazole 20 mg b.i.d. followed by omeprazole 20 mg per day for 2-6 weeks are described. In one patient, gastric giardiasis occurred in the presence of only mild intestinal metaplasia. In the other patient, Giardia lamblia infection had resolved 4 weeks after the cessation of omeprazole treatment, which, to our knowledge, is the first case reported in the literature. It is tempting to speculate that gastric giardiasis can develop in the absence of mucosal abnormalities during hypochlorhydria induced by treatment with a high dose of a proton-pump inhibitor. Specific treatment may not be required if the drug can be stopped and no other gastric disease causing hypochlorhydria is present.
本文描述了两名患者，他们在接受奥美拉唑20毫克每日两次治疗2周后，接着每日服用奥美拉唑20毫克，持续2 - 6周，之后出现了胃贾第虫病。其中一名患者在仅存在轻度肠化生的情况下发生了胃贾第虫病。另一名患者在奥美拉唑治疗停止4周后，蓝氏贾第鞭毛虫感染已消退，据我们所知，这是文献中报道的首例。很容易推测，在高剂量质子泵抑制剂治疗引起胃酸缺乏期间，即使没有黏膜异常也可能发生胃贾第虫病。如果能够停用药物且不存在其他导致胃酸缺乏的胃部疾病，则可能不需要进行特殊治疗。
