Dragunow M, Abraham W, Hughes P
Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand.
Brain Res Mol Brain Res. 1996 Mar;36(2):349-56. doi: 10.1016/0169-328x(95)00294-3.
Using in situ hybridization, we show that the expression of the immediately-early gene, nur-77, increases rapidly and transiently in hippocampal neurons following activation of muscarinic and N-methyl-D-aspartate receptors and after hippocampal long-term potentiation (LTP). On the basis of these results we hypothesize that nur-77 may coordinate with other transcription factors to initiate subsequent changes in hippocampal gene expression associated with plasticity-related activation of N-methyl-D-aspartate and muscarinic receptors.
通过原位杂交技术，我们发现即刻早期基因nur-77的表达在毒蕈碱型和N-甲基-D-天冬氨酸受体激活后以及海马长时程增强（LTP）后，在海马神经元中迅速且短暂地增加。基于这些结果，我们推测nur-77可能与其他转录因子协同作用，以启动随后与N-甲基-D-天冬氨酸和毒蕈碱型受体可塑性相关激活有关的海马基因表达变化。
