[创伤后膝关节积液中的蛋白酶及其抑制剂]

[Proteases and their inhibitors in posttraumatic knee joint effusion].

作者信息

Kunz E, Blattert T R, Weckbach A

机构信息

Chirurgische Universitätsklinik und-Poliklinik Würzburg.

出版信息

Z Orthop Ihre Grenzgeb. 1996 Sep-Oct;134(5):426-9. doi: 10.1055/s-2008-1037432.

DOI:10.1055/s-2008-1037432

Abstract

Humoral aspects are being discussed in development of arthrosis. Punctuate of 144 traumatized knee joints has been investigated. Proteolytic enzymes elastase and cathepsin D were assessed. Furthermore, protease inhibitors alpha 1-antitrypsin and alpha 2-macroglobulin were determined. Activity of chondrolytic enzymes elastase and cathepsin D clearly correlates with the clinical severity of injuries. At the same time, primary inhibitory mechanisms for compensation seem to be non-sufficient, however.

摘要

在关节病的发展过程中，体液方面的因素正在被探讨。对144个受伤膝关节进行了穿刺检查。评估了蛋白水解酶弹性蛋白酶和组织蛋白酶D。此外，还测定了蛋白酶抑制剂α1-抗胰蛋白酶和α2-巨球蛋白。溶软骨酶弹性蛋白酶和组织蛋白酶D的活性与损伤的临床严重程度明显相关。然而，与此同时，补偿的主要抑制机制似乎并不充分。

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