CD22调节非胸腺依赖性反应和B细胞的寿命。

CD22 regulates thymus-independent responses and the lifespan of B cells.

作者信息

Otipoby K L, Andersson K B, Draves K E, Klaus S J, Farr A G, Kerner J D, Perlmutter R M, Law C L, Clark E A

机构信息

Department of Immunology, University of Washington Medical Center, Seattle 98195, USA.

出版信息

Nature. 1996;384(6610):634-7. doi: 10.1038/384634a0.

DOI:10.1038/384634a0

PMID:8967951

Abstract

The B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells, and is capable of binding to ligands on T and B cells. CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling molecules, including the protein tyrosine phosphatase SHP1 (PTP1C, SHP), a putative negative regulator of BCR signalling. Thus CD22 may facilitate interactions with lymphocytes and regulate the threshold of BCR signalling. To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells.

摘要

B淋巴细胞限制性糖蛋白CD22在成熟的IgM+IgD+B细胞上表达，并且能够与T细胞和B细胞上的配体结合。CD22可与B细胞抗原受体（BCR）复合物及信号分子相互作用，其中包括蛋白酪氨酸磷酸酶SHP1（PTP1C，SHP），它被认为是BCR信号传导的负调节因子。因此，CD22可能有助于与淋巴细胞相互作用并调节BCR信号传导的阈值。为了确定CD22在体内的功能，我们培育出了CD22缺陷型小鼠。在此我们表明，CD22是对胸腺非依赖性抗原产生正常抗体反应所必需的，并且调节成熟B细胞的寿命。