Ikuta N, Taniguchi H, Kondoh Y, Takagi K, Hayakawa T
Department of Respiratory Medicine, Tosei General Hospital, Seto.
Intern Med. 1996 Nov;35(11):855-60. doi: 10.2169/internalmedicine.35.855.
Neutrophils are reported to be a major factor in the pathogenesis of the adult respiratory distress syndrome (ARDS). We measured serial levels of circulatory interleukin (IL)-8 and neutrophil elastase in 16 patients with ARDS at the onset, on day 3 and on day 7 and studied the relationship of these levels to the clinical course. Circulatory IL-8 levels of all the patients at the onset were significantly elevated compared with controls, mean +/- SE, 30.0 +/- 6.7 pg/ml and 3.3 +/- 0.3 pg/ ml, respectively. There was a significant correlation between IL-8 and neutrophil elastase levels at the onset (r = 0.65, p < 0.01). In nonsurvivors circulatory IL-8 levels were significantly higher than those of survivors throughout the study. There were significant differences in oxygenation, as reflected by PaO2/FIO2 ratios, between survivors and nonsurvivors at day 7, mean +/- SE, 208.5 +/- 21.9 and 113.5 +/- 9.6, respectively. In conclusion, we have shown that the level of circulatory IL-8 is elevated in patients with ARDS, and sustained high levels of circulatory IL-8 might be correlated with a poor outcome.
据报道，中性粒细胞是成人呼吸窘迫综合征（ARDS）发病机制中的一个主要因素。我们对16例ARDS患者在发病时、第3天和第7天的循环白细胞介素（IL）-8和中性粒细胞弹性蛋白酶水平进行了连续测定，并研究了这些水平与临床病程的关系。所有患者发病时的循环IL-8水平与对照组相比均显著升高，平均值±标准误分别为30.0±6.7 pg/ml和3.3±0.3 pg/ml。发病时IL-8与中性粒细胞弹性蛋白酶水平之间存在显著相关性（r = 0.65，p < 0.01）。在整个研究过程中，非存活者的循环IL-8水平显著高于存活者。第7天时，存活者和非存活者之间的氧合情况存在显著差异，以PaO2/FIO2比值反映，平均值±标准误分别为208.5±21.9和113.5±9.6。总之，我们已经表明ARDS患者循环IL-8水平升高，且循环IL-8持续高水平可能与不良预后相关。
