耐多药金黄色葡萄球菌暴发：聚类分析

Outbreak of multi-drug resistant Staphylococcus aureus: a cluster analysis.

作者信息

Yoshida J, Nagata T, Nishioka Y, Nose Y, Tanaka M

机构信息

Department of Surgery, National Shimonoseki Hospital, Japan.

出版信息

J Clin Epidemiol. 1996 Dec;49(12):1447-52. doi: 10.1016/s0895-4356(96)00277-6.

DOI:10.1016/s0895-4356(96)00277-6

PMID:8970496

Abstract

BACKGROUND

Outbreaks of multi-drug resistant Staphylococcus aureus over eight years were investigated to prevent future endemic.

METHODS

Isolates of multiresistant S. aureus underwent a cluster analysis combined with canonical discriminant analysis using bacteriologic biotyping and sensitivity to 21 drugs.

RESULTS

Of a total of 786 strains recovered from 155 in-patients, the specialty surgical ward (SW) exhibited 470 isolates (59.8%) and the general SW 214 (27.2%). Among six clusters formed, four clusters were predominant in the general SW. An ordination diagram from the canonical discriminant analysis revealed a distribution in which clusters were localized temporally (year) and spatially (ward). A yearly shift of clusters indicated emergence of a new phenotype of multiresistant S. aureus.

CONCLUSIONS

The cluster analysis of isolates of multiresistant S. aureus using biotyping and sensitivity may supplement the classical method of tracing the spreading patterns of this microbe.

摘要

背景

对八年来耐多药金黄色葡萄球菌的暴发情况进行了调查，以预防未来的地方流行。

方法

对多重耐药金黄色葡萄球菌分离株进行聚类分析，并结合典型判别分析，采用细菌生物分型和对21种药物的敏感性进行分析。

结果

从155名住院患者中总共分离出786株菌株，其中专科外科病房（SW）有470株（59.8%），普通外科病房有214株（27.2%）。在形成的六个聚类中，四个聚类在普通外科病房中占主导地位。典型判别分析的排序图显示了聚类在时间（年份）和空间（病房）上的分布情况。聚类的逐年变化表明出现了一种新的耐多药金黄色葡萄球菌表型。